Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 known ✓ | P21917 | 1/20 | 0.63 |
| ▸ | ADRA1D known ✓ | P25100 | 1/20 | 0.63 |
| ▸ | DRD3 known ✓ | P35462 | 1/20 | 0.63 |
| ▸ | FFAR1 | O14842 | 20/20 | 0.83 |
| ▸ | FFAR4 | Q5NUL3 | 5/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3631337 | 0.97 | FFAR1 (0.88) | FFAR1FFAR4DRD4ADRA1DDRD3 | |
| SCHEMBL3622866 | 0.94 | FFAR1 (0.94) | FFAR1FFAR4DRD4ADRA1DDRD3 | |
| SCHEMBL3631338 | 0.91 | FFAR1 (1.00) | FFAR1FFAR4DRD4ADRA1DDRD3 | |
| SCHEMBL3625868 | 0.88 | FFAR1 (0.73) | FFAR1FFAR4DRD4ADRA1DDRD3 | |
| SCHEMBL3631308 | 0.87 | FFAR1 (0.71) | FFAR1FFAR4DRD4ADRA1DDRD3 | |
| SCHEMBL3633081 | 0.85 | FFAR1 (0.60) | FFAR1FFAR4DRD4ADRA1DDRD3 | |
| SCHEMBL5104878 | 0.84 | FFAR1 (0.88) | FFAR1FFAR4DRD4ADRA1DDRD3 | |
| SCHEMBL3628407 | 0.83 | FFAR1 (0.76) | FFAR1FFAR4 | |
| SCHEMBL3625869 | 0.82 | FFAR1 (0.82) | FFAR1FFAR4DRD4ADRA1DDRD3 | |
| SCHEMBL3625974 | 0.81 | FFAR1 (0.89) | FFAR1FFAR4DRD4ADRA1DDRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7786165-B2 | Aminophenylpropanoic acid derivative | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-08-31 | — | — | US | disclosed |
| US-20080269220-A1 | Aminophenylpropanoic Acid Derivative | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-10-30 | — | — | US | disclosed |
| EP-1726580-A1 | AMINOPHENYLPROPANOIC ACID DERIVATIVE | Takeda Pharmaceutical Company Limited (JP) | 2006-11-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080269220-A1 | Aminophenylpropanoic Acid Derivative | GPR119, GPR55, GPR65 | DRD4 2571/4885ADRA1D 67/4885DRD3 1503/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.