Known targets — ChEMBL curated mechanism
GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ
The experimentally established mechanism targets of Propofol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 known ✓ | P14867 | 8/20 | 1.00 |
| ▸ | GABRB1 known ✓ | P18505 | 5/20 | 1.00 |
| ▸ | GABRB2 known ✓ | P47870 | 4/20 | 1.00 |
| ▸ | GABRG2 known ✓ | P18507 | 2/20 | 1.00 |
| ▸ | GABRB3 known ✓ | P28472 | 2/20 | 1.00 |
| ▸ | GABRA5 known ✓ | P31644 | 1/20 | 1.00 |
| ▸ | GABRA3 known ✓ | P34903 | 1/20 | 1.00 |
| ▸ | GABRA2 known ✓ | P47869 | 1/20 | 1.00 |
| ▸ | GABRA4 known ✓ | P48169 | 1/20 | 1.00 |
| ▸ | GABRA6 known ✓ | Q16445 | 1/20 | 1.00 |
| ▸ | CA1 | P00915 | 2/20 | 1.00 |
| ▸ | CA2 | P00918 | 2/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 2/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 2/20 | 1.00 |
| ▸ | LMNA | P02545 | 2/20 | 1.00 |
| ▸ | FAAH | O00519 | 1/20 | 1.00 |
| ▸ | HPGD | P15428 | 1/20 | 1.00 |
| ▸ | TSHR | P16473 | 1/20 | 1.00 |
| ▸ | PTGS1 | P23219 | 1/20 | 1.00 |
| ▸ | SLC6A2 | P23975 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propofol SCHEMBL2414429 | 1.00 | GABRA1 (1.00) | GABRA1GABRB1GABRB2CA1CA2 | |
| Propofol SCHEMBL10968616 | 0.97 | GABRA1 (0.94) | GABRA1GABRB1GABRB2CA1CA2 | |
| Propofol SCHEMBL1033835 | 0.97 | GABRA1 (0.94) | GABRA1GABRB1GABRB2CA1CA2 | |
| Propofol SCHEMBL5087474 | 0.97 | GABRA1 (0.94) | GABRA1GABRB1GABRB2CA1CA2 | |
| Propofol SCHEMBL5036811 | 0.97 | GABRA1 (0.94) | GABRA1GABRB1GABRB2CA1CA2 | |
| Propofol SCHEMBL8935177 | 0.97 | GABRA1 (0.94) | GABRA1GABRB1GABRB2CA1CA2 | |
| Propofol SCHEMBL4088686 | 0.97 | GABRA1 (0.94) | GABRA1GABRB1GABRB2CA1CA2 | |
| Propofol SCHEMBL10968613 | 0.97 | GABRA1 (0.94) | GABRA1GABRB1GABRB2CA1CA2 | |
| Propofol SCHEMBL8026569 | 0.97 | GABRA1 (0.94) | GABRA1GABRB1GABRB2CA1CA2 | |
| Propofol SCHEMBL28506127 | 0.97 | GABRA1 (0.94) | GABRA1GABRB1GABRB2CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 34088 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12635940-B2 | Closed-loop drug infusion system with synergic control | UNIVERSIDAD POLITÉCNICA DE MADRID FUNDACION PARA LA INVESTIGACIÓN E INNOVACIÓN BIOMÉDICA (ES) | 2026-05-26 | — | — | US | claimed |
| CN-122094963-A | Cardioprotective lipids and methods of use | — | 2026-05-26 | — | — | CN | claimed |
| US-12635895-B2 | Systems and methods for monitoring intracranial compliance | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2026-05-26 | — | — | US | claimed |
| CN-117362289-B | Method for synthesizing 3-acyl imidazo [1,5-a ] pyridine compound | SHANGHAI INSTITUTE OF TECHNOLOGY (CN) | 2026-05-26 | — | — | CN | claimed |
| WO-2026101534-A1 | MYOSTATIN AND ACTIVIN A IMMUNOGENS AND METHODS OF USE | VAXXINITY, INC. (US) | 2026-05-15 | — | — | WO | claimed |
| CN-122037020-A | Supported catalyst, preparation method thereof and application thereof in olefin polymerization | 中国石油化工股份有限公司 | 2026-05-15 | — | — | CN | claimed |
| WO-2026100654-A1 | NUCLEIC ACID INTRODUCTION AID, NUCLEIC ACID INTRODUCTION AGENT, AND NUCLEIC ACID INTRODUCTION METHOD | 株式会社インファーマシア | 2026-05-15 | — | — | WO | claimed |
| US-20260132404-A1 | MODIFIED OLIGONUCLEOTIDES AND DOUBLE-STRANDED RNAS | ALNYLAM PHARMACEUTICALS, INC. (US) | 2026-05-14 | — | — | US | claimed |
| US-12617754-B2 | Process for synthesizing lipids | BRISTOL-MYERS SQUIBB COMPANY (US) | 2026-05-05 | — | — | US | claimed |
| EP-4731083-A1 | TRACKING THE LEVEL OF ANESTHESIA-MEDIATED UNCONSCIOUSNESS | Massachusetts Institute of Technology (US) | 2026-04-29 | — | — | EP | claimed |
| EP-0001698-B1 | ISOMERISATION AND PRODUCTION OF ALKYLPHENOLS | STAUFFER CHEMICAL COMPANY (US) | 1981-10-21 | — | — | EP | claimed |
| US-4246383-A | Process for polymerizing olefins in the presence of a catalyst prepared from an organomagnesium component which does not reduce TiCl4 | THE DOW CHEMICAL COMPANY (US) | 1981-01-20 | — | — | US | claimed |
| US-4244838-A | High efficiency catalyst for polymerizing olefins | THE DOW CHEMICAL COMPANY (US) | 1981-01-13 | — | — | US | claimed |
| US-4167613-A | UNSATURATED POLYESTERS | PENNWALT CORPORATION (US) | 1979-09-11 | — | — | US | claimed |
| EP-0001698-A1 | Isomerisation and production of alkylphenols | STAUFFER CHEMICAL COMPANY (US) | 1979-05-02 | — | — | EP | claimed |
| US-4117178-A | PHENOLIC ANTIOXIDANTS FOR NON-POLYMERIC HALOGEN COMPOUNDS DURING IMPREGNATION OF STYRENE POLYMER PARTICLES | ARCO POLYMERS, INC. (US) | 1978-09-26 | — | — | US | claimed |
| US-4113672-A | Molding expandable styrene polymer particles | ARCO POLYMERS, INC. (US) | 1978-09-12 | — | — | US | claimed |
| US-4060468-A | TUNGSTEN CONTAINING | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 1977-11-29 | — | — | US | claimed |
| US-3954889-A | Process for the production of 1,1,3,3-substituted hydroxyindanes | BAYER AKTIENGESELLSCHAFT (DT) | 1976-05-04 | — | — | US | claimed |
| US-3931228-A | Process for preparing phthalide and naphthalide indicator dyes | POLAROID CORPORATION (US) | 1976-01-06 | — | — | US | claimed |