Known targets — ChEMBL curated mechanism
GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ
The experimentally established mechanism targets of Propofol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 known ✓ | P14867 | 8/20 | 0.94 |
| ▸ | GABRB1 known ✓ | P18505 | 5/20 | 0.94 |
| ▸ | GABRB2 known ✓ | P47870 | 4/20 | 0.94 |
| ▸ | GABRG2 known ✓ | P18507 | 2/20 | 0.94 |
| ▸ | GABRB3 known ✓ | P28472 | 2/20 | 0.94 |
| ▸ | GABRA5 known ✓ | P31644 | 1/20 | 0.94 |
| ▸ | GABRA3 known ✓ | P34903 | 1/20 | 0.94 |
| ▸ | GABRA2 known ✓ | P47869 | 1/20 | 0.94 |
| ▸ | GABRA4 known ✓ | P48169 | 1/20 | 0.94 |
| ▸ | GABRA6 known ✓ | Q16445 | 1/20 | 0.94 |
| ▸ | CA1 | P00915 | 2/20 | 0.94 |
| ▸ | CA2 | P00918 | 2/20 | 0.94 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.94 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.94 |
| ▸ | LMNA | P02545 | 2/20 | 0.94 |
| ▸ | FAAH | O00519 | 1/20 | 0.94 |
| ▸ | HPGD | P15428 | 1/20 | 0.94 |
| ▸ | TSHR | P16473 | 1/20 | 0.94 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.94 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.94 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propofol SCHEMBL6040021 | 0.97 | GABRA1 (0.90) | GABRA1GABRB1GABRB2CA1CA2 | |
| Propofol SCHEMBL2414429 | 0.97 | GABRA1 (1.00) | GABRA1GABRB1GABRB2CA1CA2 | |
| Propofol SCHEMBL36245 | 0.97 | GABRA1 (1.00) | GABRA1GABRB1GABRB2CA1CA2 | |
| Propofol SCHEMBL10968616 | 0.94 | GABRA1 (0.94) | GABRA1GABRB1GABRB2CA1CA2 | |
| Propofol SCHEMBL5036811 | 0.94 | GABRA1 (0.94) | GABRA1GABRB1GABRB2CA1CA2 | |
| Propofol SCHEMBL8935177 | 0.94 | GABRA1 (0.94) | GABRA1GABRB1GABRB2CA1CA2 | |
| Propofol SCHEMBL8026569 | 0.94 | GABRA1 (0.94) | GABRA1GABRB1GABRB2CA1CA2 | |
| Propofol SCHEMBL1033835 | 0.94 | GABRA1 (0.94) | GABRA1GABRB1GABRB2CA1CA2 | |
| Propofol SCHEMBL10968613 | 0.94 | GABRA1 (0.94) | GABRA1GABRB1GABRB2CA1CA2 | |
| Propofol SCHEMBL5087474 | 0.94 | GABRA1 (0.94) | GABRA1GABRB1GABRB2CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957546-B1 | CATALYSTS FOR OLEFIN POLYMERIZATION | CHEVRON PHILLIPS CHEMICAL CO (US) | 2012-10-31 | — | — | EP | claimed |
| EP-1957546-A1 | CATALYSEURS DE LA POLYMERISATION DES OLEFINES | Chevron Phillips Chemical Company LP (US) | 2008-08-20 | — | — | EP | claimed |
| WO-2007059200-A1 | CATALYSEURS DE LA POLYMERISATION DES OLEFINES | CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) | 2007-05-24 | — | — | WO | claimed |
| US-20070111883-A1 | Catalysts for olefin polymerization | CHEVRON PHILLIPS CHEMICAL COMPANY, LP | 2007-05-17 | — | — | US | claimed |
| EP-1957546-B1 | CATALYSTS FOR OLEFIN POLYMERIZATION | CHEVRON PHILLIPS CHEMICAL CO (US) | 2012-10-31 | — | — | EP | disclosed |
| US-7534842-B2 | Catalysts for olefin polymerization | CHEVRON PHILLIPS CHEMICAL COMPANY, LP (US) | 2009-05-19 | — | — | US | disclosed |
| EP-1957546-A1 | CATALYSEURS DE LA POLYMERISATION DES OLEFINES | Chevron Phillips Chemical Company LP (US) | 2008-08-20 | — | — | EP | disclosed |
| WO-2007059200-A1 | CATALYSEURS DE LA POLYMERISATION DES OLEFINES | CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) | 2007-05-24 | — | — | WO | disclosed |
| US-20070111883-A1 | Catalysts for olefin polymerization | CHEVRON PHILLIPS CHEMICAL COMPANY, LP | 2007-05-17 | — | — | US | disclosed |