SCHEMBL3624640

SCHEMBL3624640

NC(=O)C1OCCC1(C(=O)O)S(=O)(=O)c1ccc(Oc2ccc(F)cc2)cc1

nearest known ligand 0.42

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
MMP1 P03956 17/20 0.42
MMP13 P45452 14/20 0.42
MMP2 P08253 7/20 0.42
MMP3 P08254 7/20 0.42
MMP9 P14780 7/20 0.42
MMP8 P22894 6/20 0.42
MMP14 P50281 6/20 0.42
MMP12 P39900 1/20 0.42
SOS1 Q07889 1/20 0.41
KCNH2 Q12809 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25364 0.80 MMP1 (0.52) MMP1MMP13MMP2MMP3MMP9
SCHEMBL7208148 0.70 MMP1 (0.52) MMP1MMP13MMP2MMP3MMP9
SCHEMBL7209180 0.69 MMP1 (0.57) MMP1MMP13MMP2MMP3MMP9
SCHEMBL7213095 0.69 MMP1 (0.49) MMP1MMP13MMP2MMP3MMP9
SCHEMBL7208607 0.69 MMP1 (0.52) MMP1MMP13MMP2MMP3MMP9
SCHEMBL7209154 0.68 MMP1 (0.47) MMP1MMP13MMP2MMP3MMP9
SCHEMBL7209196 0.68 MMP1 (0.53) MMP1MMP13MMP2MMP3MMP9
SCHEMBL7212961 0.66 MMP1 (0.48) MMP1MMP13MMP2MMP3MMP9
Hydroxyamine SCHEMBL5914587 0.66 MMP1 (0.76) MMP1MMP13MMP2MMP3MMP9
SCHEMBL2575324 0.65 MMP1 (0.79) MMP1MMP13MMP2MMP3MMP9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7700742-B2 gene therapy; immunoglobulins; hybridomas; monoclonal antibodies AMGEN FREMONT (US) 2010-04-20 US disclosed