Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOD1 | Q9Y239 | 9/20 | 0.50 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.48 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.48 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.47 |
| ▸ | TGM2 | P21980 | 1/20 | 0.46 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.45 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.45 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3629433 | 0.98 | NOD1 (0.53) | NOD1SIRT2SIRT1EPHX1SLC6A5 | |
| SCHEMBL8973585 | 0.95 | NOD1 (0.55) | NOD1SIRT2SIRT1EPHX1SLC6A5 | |
| SCHEMBL7382637 | 0.95 | NOD1 (0.48) | NOD1SIRT2SIRT1EPHX1TGM2 | |
| SCHEMBL1077922 | 0.95 | NOD1 (0.48) | NOD1SIRT2SIRT1EPHX1TGM2 | |
| SCHEMBL5970938 | 0.92 | ACHE (0.49) | NOD1SIRT2SIRT1EPHX1TGM2 | |
| SCHEMBL3655323 | 0.92 | ITGB3 (0.46) | NOD1EPHX1TGM2ITGB3ITGA2B | |
| SCHEMBL283288 | 0.92 | ITGB3 (0.46) | NOD1EPHX1TGM2ITGB3ITGA2B | |
| SCHEMBL284211 | 0.92 | ITGB3 (0.46) | NOD1EPHX1TGM2ITGB3ITGA2B | |
| SCHEMBL7534565 | 0.91 | SLC6A5 (0.52) | NOD1SIRT2SIRT1TGM2ITGB3 | |
| SCHEMBL2356099 | 0.91 | SLC6A5 (0.52) | NOD1SIRT2SIRT1TGM2ITGB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2200439-A1 | HDAC INHIBITORS | Lixte Biotechnology, Inc. (US) | 2010-06-30 | — | — | EP | disclosed |
| WO-2009045440-A1 | HDAC INHIBITORS | LIXTE BIOTECHNOLOGY HOLDINGS, INC. (US) | 2009-04-09 | — | — | WO | disclosed |
| EP-1093367-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2003-03-05 | — | — | EP | disclosed |
| EP-1093367-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-04-25 | — | — | EP | disclosed |
| WO-1999066925-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-12-29 | — | — | WO | disclosed |