SCHEMBL36283

SCHEMBL36283

COC(=O)c1ccc(OC)c(Br)c1

nearest known ligand 0.73

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.73
CYP1A2 P05177 4/20 0.63
CYP2C19 P33261 4/20 0.63
CYP2D6 P10635 1/20 0.63
HPGD P15428 1/20 0.63
MAPT P10636 7/20 0.62
NOTUM Q6P988 1/20 0.58
L3MBTL1 Q9Y468 1/20 0.56
KMT2A Q03164 5/20 0.55
MEN1 O00255 3/20 0.55
ALOX12 P18054 2/20 0.55
CYP3A4 P08684 2/20 0.55
CYP2C9 P11712 1/20 0.55
RAB9A P51151 1/20 0.55
NPSR1 Q6W5P4 1/20 0.55
GAA P10253 1/20 0.55
PKM P14618 1/20 0.55
GLA P06280 1/20 0.54
RECQL P46063 1/20 0.54
KCNH2 Q12809 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29810107 1.00 ALDH1A1 (0.73) ALDH1A1CYP1A2CYP2C19CYP2D6HPGD
SCHEMBL2269669 0.90 ALDH1A1 (0.81) ALDH1A1CYP1A2CYP2C19CYP2D6HPGD
SCHEMBL426745 0.85 MAPT (0.62) ALDH1A1CYP1A2CYP2C19CYP2D6HPGD
SCHEMBL27630437 0.85 ALDH1A1 (1.00) ALDH1A1CYP1A2CYP2C19CYP2D6HPGD
SCHEMBL1639358 0.84 NOTUM (0.54) ALDH1A1CYP1A2CYP2C19CYP2D6HPGD
SCHEMBL313116 0.83 ALDH1A1 (0.76) ALDH1A1CYP1A2CYP2C19CYP2D6HPGD
SCHEMBL36091 0.83 ALDH1A1 (0.76) ALDH1A1CYP1A2CYP2C19CYP2D6HPGD
SCHEMBL31652866 0.83 ALDH1A1 (0.76) ALDH1A1CYP1A2CYP2C19CYP2D6HPGD
SCHEMBL1980076 0.83 NOTUM (0.56) ALDH1A1CYP1A2CYP2C19CYP2D6HPGD
SCHEMBL21836873 0.83 ALDH1A1 (0.65) ALDH1A1CYP1A2CYP2C19CYP2D6HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 178 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119306597-A Preparation method of aromatic bromo-compound 阜阳欣奕华制药科技有限公司 2025-01-14 CN claimed
US-20260035341-A1 FTO INHIBITORS RPXDS CO LTD (CN) 2026-02-05 US disclosed
EP-4665339-A1 INHIBITING ALPHA V BETA 8 INTEGRIN Morphic Therapeutic, Inc. (US) 2025-12-24 EP disclosed
EP-4561975-A1 FTO INHIBITORS RPXDS Co., Ltd (CN) 2025-06-04 EP disclosed
WO-2025096751-A1 MACROCYCLIC INHIBITORS OF ATP CITRATE LYASE ESPERION THERAPEUTICS, INC. (US) 2025-05-08 WO disclosed
US-20250115597-A1 TYK2 INHIBITORS AND COMPOSITIONS AND METHODS THEREOF LYNK PHARMACEUTICALS CO LTD (CN) 2025-04-10 US disclosed
CN-119546566-A FTO inhibitors 瑞璞鑫(苏州)生物科技有限公司 2025-02-28 CN disclosed
CN-119306597-A Preparation method of aromatic bromo-compound 阜阳欣奕华制药科技有限公司 2025-01-14 CN disclosed
US-12129250-B2 TYK2 inhibitors and compositions and methods thereof LYNK PHARMACEUTICALS CO. LTD. (CN) 2024-10-29 US disclosed
EP-4448514-A1 TYK2 INHIBITORS AND COMPOSITIONS AND METHODS THEREOF Lynk Pharmaceuticals Co. Ltd. (CN) 2024-10-23 EP disclosed
US-20040186061-A1 Novel derivatives of 3,3-diphenylpropylamines SCHWARZ PHARMA AG 2004-09-23 US disclosed
US-6713464-B1 ANTIMUSCARINIC AGENTS WITH SUPERIOR PHARMACOKINETICS SCHWARZ PHARMA AG (DE) 2004-03-30 US disclosed
EP-1254890-A1 Derivatives of 3,3-diphenylpropylamines SCHWARZ PHARMA AG (DE) 2002-11-06 EP disclosed
EP-1077912-B1 NOVEL DERIVATIVES OF 3,3-DIPHENYLPROPYLAMINES SANOL ARZNEI SCHWARZ GMBH (DE) 2002-07-03 EP disclosed
CN-1354737-A Novel 3, 3-diphenylpropylamine derivatives SANOL ARZNEI SCHWARZ GMBH (DE) 2002-06-19 CN disclosed
US-6245778-B1 1,6-naphthyridine anti-convulsants SMITHKLINE BEECHAM P.L.C. (GB) 2001-06-12 US disclosed
EP-1077912-A1 NOVEL DERIVATIVES OF 3,3-DIPHENYLPROPYLAMINES SCHWARZ PHARMA AG (DE) 2001-02-28 EP disclosed
EP-0986559-A1 1,6-NAPHTHYRIDINE ANTI-CONVULSANTS SMITHKLINE BEECHAM PLC (GB) 2000-03-22 EP disclosed
WO-1999058478-A1 NOVEL DERIVATIVES OF 3,3-DIPHENYLPROPYLAMINES SCHWARZ PHARMA AG (DE) 1999-11-18 WO disclosed
WO-1998054184-A1 1,6-NAPHTHYRIDINE ANTI-CONVULSANTS SMITHKLINE BEECHAM PLC (GB) 1998-12-03 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040186061-A1 Novel derivatives of 3,3-diphenylpropylamines ADRB3, ADRA1D, TNNC1 ALDH1A1 928/4885CYP1A2 91/4885CYP2C19 115/4885
US-20260035341-A1 FTO INHIBITORS FTO, LDLR, GPR119 ALDH1A1 1334/4885CYP1A2 1674/4885CYP2C19 2844/4885
US-20250115597-A1 TYK2 INHIBITORS AND COMPOSITIONS AND METHODS THEREOF TYK2, JAK2, JAK1 ALDH1A1 4805/4885CYP1A2 3743/4885CYP2C19 3748/4885
US-12129250-B2 TYK2 inhibitors and compositions and methods thereof TYK2, JAK2, JAK1 ALDH1A1 4805/4885CYP1A2 3743/4885CYP2C19 3748/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.