Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.46 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.45 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.45 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.45 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | MMP7 | P09237 | 1/20 | 0.43 |
| ▸ | MMP14 | P50281 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MPO | P05164 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL59198 | 0.82 | KEAP1 (0.65) | KEAP1PTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL1283787 | 0.79 | PSIP1 (0.48) | HSD11B1PTGDR2ALDH1A1KMT2ATSHR | |
| SCHEMBL8674130 | 0.78 | NPSR1 (0.44) | KEAP1HSD11B1MEN1ALDH1A1KMT2A | |
| SCHEMBL27575272 | 0.78 | PSIP1 (0.47) | HSD11B1PTGDR2ALDH1A1TSHRHSD17B10 | |
| SCHEMBL11922695 | 0.77 | PSIP1 (0.61) | HSD11B1PTGDR2ALDH1A1KMT2ATSHR | |
| SCHEMBL9617614 | 0.76 | ALDH1A1 (0.47) | KEAP1MEN1ALDH1A1KMT2APTGER1 | |
| SCHEMBL3147023 | 0.76 | PSIP1 (0.48) | HSD11B1PTGDR2MEN1ALDH1A1KMT2A | |
| SCHEMBL1714597 | 0.76 | PSIP1 (0.48) | HSD11B1PTGDR2MEN1ALDH1A1KMT2A | |
| SCHEMBL3728799 | 0.75 | CYP4F2 (0.58) | KEAP1PTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL8573204 | 0.75 | KEAP1 (0.56) | KEAP1PTGER1PTGER4PTGER3PTGER2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2229942-A1 | 2-Aryl-propionic acids and pharmaceutical compositions containing them | Dompe S.p.A. (IT) | 2010-09-22 | — | — | EP | disclosed |