Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.42 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.42 |
| ▸ | CTSD | P07339 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4345297 | 0.88 | NPC1 (0.60) | RAB9ANPC1MAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL5404802 | 0.87 | ALDH1A1 (0.52) | RAB9ANPC1MAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL23152216 | 0.81 | CTSD (0.50) | RAB9AMAPTSMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL10935027 | 0.81 | ALDH1A1 (0.52) | RAB9AHPGDALDH1A1HSD17B10KDM4E | |
| SCHEMBL4799007 | 0.79 | ALDH1A1 (0.50) | RAB9ANPC1MAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL2420501 | 0.79 | ALDH1A1 (0.50) | RAB9ANPC1MAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL6562825 | 0.78 | ALDH1A1 (0.66) | RAB9AMAPTSMN1; SMN2L3MBTL1HPGD | |
| SCHEMBL503962 | 0.78 | ALDH1A1 (0.61) | RAB9AL3MBTL1HPGDALDH1A1HSD17B10 | |
| SCHEMBL30393029 | 0.78 | ALDH1A1 (0.61) | RAB9AL3MBTL1HPGDALDH1A1HSD17B10 | |
| SCHEMBL27720646 | 0.77 | KCNA3 (0.56) | RAB9ANPC1MAPTSMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155704-A1 | THIADIAZOLE DERIVATIVES AS ANTIDIABETIC AGENTS | Novartis Ag (CH) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008148744-A1 | THIADIAZOLE DERIVATIVES AS ANTIDIABETIC AGENTS | NOVARTIS AG (CH) | 2008-12-11 | — | — | WO | disclosed |