Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
| ▸ | HTR6 | P50406 | 1/20 | 0.44 |
| ▸ | FABP4 | P15090 | 2/20 | 0.41 |
| ▸ | SCN2B | O60939 | 3/20 | 0.40 |
| ▸ | SCN1B | Q07699 | 3/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.40 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.40 |
| ▸ | SCN1A | P35498 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NQO2 | P16083 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | PER2 | O15055 | 1/20 | 0.37 |
| ▸ | CRY1 | Q16526 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3632244 | 0.74 | SLC6A2 (0.56) | SLC6A2HTR6FABP4HDAC1HDAC2 | |
| SCHEMBL8836040 | 0.74 | SLC6A2 (0.51) | SLC6A2HTR6FABP4HDAC1HDAC2 | |
| SCHEMBL11452265 | 0.74 | SLC6A2 (0.51) | SLC6A2HTR6FABP4HDAC1HDAC2 | |
| SCHEMBL2692814 | 0.73 | HTR6 (0.59) | SLC6A2HTR6FABP4KMT2AMEN1 | |
| SCHEMBL8836604 | 0.69 | FABP4 (0.51) | SLC6A2FABP4HDAC1HDAC2HDAC8 | |
| SCHEMBL3978255 | 0.69 | SLC6A2 (0.50) | SLC6A2HTR6HDAC1HDAC2HDAC8 | |
| SCHEMBL8835800 | 0.69 | SLC6A2 (0.47) | SLC6A2HTR6FABP4HDAC1HDAC2 | |
| SCHEMBL146530 | 0.69 | GPR84 (0.57) | KMT2AKDM4ENQO2ALDH1A1IMPDH2 | |
| SCHEMBL29473770 | 0.69 | GPR84 (0.57) | KMT2AKDM4ENQO2ALDH1A1IMPDH2 | |
| SCHEMBL3626398 | 0.68 | HTT (0.51) | SLC6A2HTR6KMT2AMEN1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2142516-A1 | PYRIMIDINE HYDRAZIDE COMPOUNDS AS PGDS INHIBITORS | Sanofi-Aventis (FR) | 2010-01-13 | — | — | EP | disclosed |
| WO-2008121670-A1 | PYRIMIDINE HYDRAZIDE COMPOUNDS AS PGDS INHIBITORS | SANOFI-AVENTIS (FR) | 2008-10-09 | — | — | WO | disclosed |