Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 3/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 6/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | GPBAR1 | Q8TDU6 | 4/20 | 0.34 |
| ▸ | PPARD | Q03181 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | GCG | P01275 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL363112 | 0.93 | GPBAR1 (0.36) | GCGREPHX2ALDH1A1POLBGPBAR1 | |
| SCHEMBL362797 | 0.91 | GCGR (0.39) | GCGREPHX2S1PR1S1PR3ALDH1A1 | |
| SCHEMBL363032 | 0.86 | GPBAR1 (0.45) | EPHX2POLBGPBAR1BRD4 | |
| SCHEMBL363811 | 0.85 | S1PR1 (0.36) | GCGREPHX2S1PR1S1PR3ALDH1A1 | |
| SCHEMBL362795 | 0.83 | GPBAR1 (0.36) | GCGREPHX2ALDH1A1POLBGPBAR1 | |
| SCHEMBL361680 | 0.83 | GPBAR1 (0.47) | GCGRS1PR1S1PR3POLBGPBAR1 | |
| SCHEMBL1390150 | 0.83 | EPHX2 (0.35) | GCGREPHX2S1PR1S1PR3GPBAR1 | |
| SCHEMBL1390151 | 0.83 | EPHX2 (0.35) | GCGREPHX2S1PR1S1PR3GPBAR1 | |
| SCHEMBL363696 | 0.82 | BRD4 (0.36) | GCGRS1PR1S1PR3ALDH1A1BRD4 | |
| SCHEMBL363248 | 0.80 | GPBAR1 (0.41) | S1PR1S1PR3GPBAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593426-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-05-22 | — | — | EP | claimed |
| WO-2012007365-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-19 | — | — | WO | claimed |
| EP-2593426-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012007365-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-19 | — | — | WO | disclosed |