Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | USP14 | P54578 | 2/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.35 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2677338 | 0.89 | USP14 (0.41) | MEN1KMT2ANPC1RAB9ADRD2 | |
| SCHEMBL3632605 | 0.84 | ALDH1A1 (0.37) | KMT2AUSP14 | |
| SCHEMBL3635178 | 0.83 | KMT2A (0.39) | MEN1KMT2A | |
| SCHEMBL2676863 | 0.83 | ALDH1A1 (0.40) | MEN1KMT2AOPRM1OPRD1OPRK1 | |
| SCHEMBL2675206 | 0.83 | ALDH1A1 (0.40) | MEN1KMT2AOPRM1OPRD1OPRK1 | |
| SCHEMBL2675209 | 0.83 | ALDH1A1 (0.40) | MEN1KMT2AOPRM1OPRD1OPRK1 | |
| SCHEMBL2677815 | 0.81 | HTR1A (0.46) | MEN1KMT2ADRD2 | |
| SCHEMBL2676766 | 0.80 | MCL1 (0.46) | MEN1KMT2ADRD2DRD4DRD3 | |
| SCHEMBL3632002 | 0.80 | ADRA1D (0.42) | MEN1KMT2ADRD2DRD3 | |
| SCHEMBL2676260 | 0.80 | ACHE (0.45) | MEN1KMT2ADRD2DRD4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2150534-A1 | ISOQUINOLINONE DERIVATIVES AS NK3 ANTAGONISTS | H. Lundbeck A/S (DK) | 2010-02-10 | — | — | EP | claimed |
| WO-2008131779-A1 | ISOQUINOLINONE DERIVATIVES AS NK3 ANTAGONISTS | H. LUNDBECK A/S (DK) | 2008-11-06 | — | — | WO | claimed |