Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 7/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.71 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.60 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.57 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.57 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.57 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.57 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.56 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.56 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | CA12 | O43570 | 2/20 | 0.54 |
| ▸ | CA1 | P00915 | 2/20 | 0.54 |
| ▸ | CA2 | P00918 | 2/20 | 0.54 |
| ▸ | CA7 | P43166 | 2/20 | 0.54 |
| ▸ | CA9 | Q16790 | 2/20 | 0.54 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31387924 | 0.98 | HPGD (0.68) | HPGDALDH1A1EPHX2PDK1PDK2 | |
| SCHEMBL31387922 | 0.98 | HPGD (0.68) | HPGDALDH1A1EPHX2PDK1PDK2 | |
| SCHEMBL2677750 | 0.87 | PDK1 (0.56) | HPGDALDH1A1EPHX2PDK1PDK2 | |
| SCHEMBL7132525 | 0.84 | HPGD (1.00) | HPGDALDH1A1MEN1TSHRKMT2A | |
| SCHEMBL27479149 | 0.84 | HPGD (1.00) | HPGDALDH1A1MEN1TSHRKMT2A | |
| SCHEMBL1376624 | 0.84 | PDK1 (0.59) | HPGDALDH1A1EPHX2PDK1PDK2 | |
| SCHEMBL1375337 | 0.84 | SIGMAR1 (0.64) | HPGDALDH1A1EPHX2PDK1PDK2 | |
| SCHEMBL2002543 | 0.84 | ALDH1A1 (0.56) | HPGDALDH1A1EPHX2PDK1PDK2 | |
| SCHEMBL13504026 | 0.83 | GRM5 (0.68) | HPGDALDH1A1PDK1PDK2PDK3 | |
| SCHEMBL21524887 | 0.83 | PHGDH (0.63) | HPGDALDH1A1PDK1PDK2PDK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220177416-A1 | PREPARING METHOD OF COMPOUNDS INCLUDING AMIDE GROUP FROM TERTIARY AMINE | Research & Business Foundation Sungkyunkwan University (KR) | 2022-06-09 | — | — | US | disclosed |
| WO-2021121420-A1 | BENZOPYRAZOLE COMPOUND AND INTERMEDIATE, PREPARATION METHOD, AND APPLICATION THEREOF | 江苏凯迪恩医药科技有限公司 | 2021-06-24 | — | — | WO | disclosed |
| CN-101790520-A | Method for preparing halogenated amines | WYETH CORP | 2010-07-28 | — | — | CN | disclosed |
| EP-2144890-A1 | METHOD FOR PREPARING HALOGENATED AMINES | Wyeth (US) | 2010-01-20 | — | — | EP | disclosed |
| WO-2008098103-A1 | METHOD FOR PREPARING HALOGENATED AMINES | WYETH (US) | 2008-08-14 | — | — | WO | disclosed |
| US-20080188659-A1 | Method for Preparing Halogenated Amines | WYETH (US) | 2008-08-07 | — | — | US | disclosed |
| US-20080188659-A1 | Method for Preparing Halogenated Amines | WYETH (US) | 2008-08-07 | — | — | US | disclosed |
| US-20080188659-A1 | Method for Preparing Halogenated Amines | WYETH (US) | 2008-08-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080188659-A1 | Method for Preparing Halogenated Amines | PNMT, ABL1, INMT | HPGD 2980/4885ALDH1A1 1194/4885EPHX2 711/4885 |
| US-20220177416-A1 | PREPARING METHOD OF COMPOUNDS INCLUDING AMIDE GROUP FROM TERTIARY AMINE | TYR, NAT1, SAT1 | HPGD 3544/4885ALDH1A1 2021/4885EPHX2 1660/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.