Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 4/20 | 0.51 |
| ▸ | NOS3 | P29474 | 3/20 | 0.51 |
| ▸ | NOS2 | P35228 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | THPO | P40225 | 1/20 | 0.51 |
| ▸ | BLM | P54132 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.45 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | OGT | O15294 | 1/20 | 0.44 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.43 |
| ▸ | KMO | O15229 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 3/20 | 0.41 |
| ▸ | CA9 | Q16790 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | GLA | P06280 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29114117 | 0.89 | NOS3 (0.54) | NOS1NOS3NOS2LMNACYP1A2 | |
| SCHEMBL30613110 | 0.89 | NOS3 (0.54) | NOS1NOS3NOS2LMNACYP1A2 | |
| SCHEMBL144518 | 0.87 | CREBBP (0.54) | NOS1TSHRPDE3BPDE3APOLB | |
| SCHEMBL3634731 | 0.83 | NOS1 (0.51) | NOS1NOS3NOS2LMNACYP1A2 | |
| SCHEMBL2188527 | 0.81 | NOS1 (0.49) | NOS1NOS3NOS2LMNACYP1A2 | |
| SCHEMBL15488614 | 0.81 | KMT2A (0.49) | NOS1NOS3NOS2LMNACYP1A2 | |
| SCHEMBL5793253 | 0.80 | LMNA (0.52) | NOS1NOS3NOS2LMNACYP1A2 | |
| SCHEMBL29447076 | 0.78 | NOS1 (0.61) | NOS1NOS3NOS2LMNACYP1A2 | |
| SCHEMBL244237 | 0.78 | NOS1 (0.61) | NOS1NOS3NOS2LMNACYP1A2 | |
| SCHEMBL9610690 | 0.76 | CREBBP (0.56) | NOS1TSHRPDE3BPDE3APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2150551-A1 | 2-OXO-3-BENZYL-BENZOXAZOL-2-ONE DERIVATIVES AND RELATED COMPOUNDS AS MET KINASE INHIBITORS FOR THE TREATMENT OF TUMORS | Merck Patent GmbH (DE) | 2010-02-10 | — | — | EP | disclosed |
| WO-2008148449-A1 | 2-OXO-3-BENZYL-BENZOXAZOL-2-ONE DERIVATIVES AND RELATED COMPOUNDS AS MET KINASE INHIBITORS FOR THE TREATMENT OF TUMORS | MERCK PATENT GMBH (DE) | 2008-12-11 | — | — | WO | disclosed |