Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | APEX1 | P27695 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | PDK2 | Q15119 | 6/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | SCN1A | P35498 | 1/20 | 0.35 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.35 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6154693 | 0.81 | MAPT (0.46) | THRBTDP1APEX1ALDH1A1MAPT | |
| SCHEMBL3890644 | 0.79 | ALOX5 (0.38) | — | |
| SCHEMBL19335310 | 0.79 | THRB (0.40) | THRBTDP1APEX1ALDH1A1MAPT | |
| SCHEMBL2774493 | 0.78 | ELANE (0.41) | THRBTDP1APEX1ALDH1A1MAPT | |
| SCHEMBL987799 | 0.78 | THRB (0.55) | THRBTDP1APEX1ALDH1A1MAPT | |
| SCHEMBL28089194 | 0.76 | THRB (0.48) | THRBTDP1APEX1ALDH1A1MAPT | |
| SCHEMBL13126124 | 0.74 | ALDH1A1 (0.38) | THRBTDP1APEX1ALDH1A1MAPT | |
| SCHEMBL28550784 | 0.74 | PDK2 (0.41) | THRBTDP1APEX1ALDH1A1MAPT | |
| SCHEMBL14135112 | 0.73 | PDK2 (0.39) | THRBTDP1APEX1ALDH1A1MAPT | |
| SCHEMBL24845694 | 0.73 | PDK2 (0.48) | THRBTDP1ALDH1A1MAPTITGA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106163517-B | Pharmaceutical compositions for the treatment of cystic fibrosis transmembrane conductance regulator mediated diseases | 沃泰克斯药物股份有限公司 | 2020-08-14 | — | — | CN | disclosed |
| CN-110840847-A | Pharmaceutical compositions for the treatment of cystic fibrosis transmembrane conductance regulator mediated diseases | 沃泰克斯药物股份有限公司 | 2020-02-28 | — | — | CN | disclosed |
| CN-106279110-A | Heterocyclic compound, medicine containing described compound and application thereof and its preparation method | 勃林格殷格翰国际有限公司 | 2017-01-04 | — | — | CN | disclosed |
| CN-104024244-B | Heterocyclic compounds, medicaments containing said compounds, their use and processes for their preparation | 勃林格殷格翰国际有限公司 | 2016-09-14 | — | — | CN | disclosed |
| CN-104024244-A | Heterocyclic compounds, medicaments containing said compounds, their use and processes for their preparation | BOEHRINGER INGELHEIM INT | 2014-09-03 | — | — | CN | disclosed |
| EP-2215092-A1 | SUBSTITUTED PIPERIDINO-DIHYDROTHIENOPYRIMIDINES | Boehringer Ingelheim International GmbH (DE) | 2010-08-11 | — | — | EP | disclosed |
| EP-2215093-A1 | NOVEL PIPERAZINO-DIHYDROTHIENOPYRIMIDINE DERIVATIVES | Boehringer Ingelheim International GmbH (DE) | 2010-08-11 | — | — | EP | disclosed |
| EP-2214673-A1 | NOVEL PHENYL-SUBSTITUTED PIPERAZINO-DIHYDROTHIENOPYRIMIDINES | Boehringer Ingelheim International GmbH (DE) | 2010-08-11 | — | — | EP | disclosed |
| EP-2205609-A2 | HETEROCYCLE-SUBSTITUTED PIPERAZINO-DIHYDROTHIENOPYRIMIDINES | Boehringer Ingelheim International GmbH (DE) | 2010-07-14 | — | — | EP | disclosed |
| EP-2179272-A1 | OPTICAL FILLING CONTROL OF PHARMACEUTICAL CAPSULES IN CAPSULE FILLING MACHINES | Boehringer Ingelheim International GmbH (DE) | 2010-04-28 | — | — | EP | disclosed |
| EP-1997819-A1 | Method for manufacturing scopinium esters | Boehringer Ingelheim Pharma GmbH & Co. KG (DE) | 2008-12-03 | — | — | EP | disclosed |
| EP-1941263-A1 | OPTICAL SEMI-QUANTITATIVE 100 % FILLING CHECK OF PHARMACEUTICAL CAPSULES ON CAPSULE FILLING MACHINES | Boehringer Ingelheim International GmbH (DE) | 2008-07-09 | — | — | EP | disclosed |
| WO-2008061873-A2 | STABLE POWDER FORMULATION CONTAINING A NOVEL ANTICHOLINERGIC AGENT | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-05-29 | — | — | WO | disclosed |
| WO-2007134968-A1 | INHALANT AEROSOL FORMULATIONS CONTAINING ETHANOL | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-11-29 | — | — | WO | disclosed |
| WO-2007134966-A1 | INHALANT PROPELLANT-FREE AEROSOL FORMULATION | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-11-29 | — | — | WO | disclosed |
| WO-2007045670-A1 | OPTICAL SEMI-QUANTITATIVE 100 % FILLING CHECK OF PHARMACEUTICAL CAPSULES ON CAPSULE FILLING MACHINES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-04-26 | — | — | WO | disclosed |
| EP-1561751-A1 | Fluorene carboxylic acid esters, methods for the production thereof, and use of the same as pharmaceuticals | Boehringer Ingelheim Pharma GmbH & Co.KG (DE) | 2005-08-10 | — | — | EP | disclosed |
| EP-1472251-B1 | NOVEL FLUORENE CARBOXYLIC ACID ESTERS, METHODS FOR THE PRODUCTION THEREOF, AND USE OF THE SAME AS PHARMACEUTICALS | BOEHRINGER INGELHEIM PHARMA (DE) | 2005-07-20 | — | — | EP | disclosed |
| EP-1472251-A1 | NOVEL FLUORENE CARBOXYLIC ACID ESTERS, METHODS FOR THE PRODUCTION THEREOF, AND USE OF THE SAME AS PHARMACEUTICALS | Boehringer Ingelheim Pharma GmbH & Co.KG (DE) | 2004-11-03 | — | — | EP | disclosed |
| WO-2003064419-A1 | NOVEL FLUORENE CARBOXYLIC ACID ESTERS, METHODS FOR THE PRODUCTION THEREOF, AND USE OF THE SAME AS PHARMACEUTICALS | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2003-08-07 | — | — | WO | disclosed |