Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 4/20 | 0.40 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.37 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 4/20 | 0.34 |
| ▸ | KDR | P35968 | 2/20 | 0.34 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.34 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.32 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL365756 | 0.89 | ADRB3 (0.38) | MRGPRX4PPARGGPBAR1P2RX3NR4A2 | |
| SCHEMBL363129 | 0.89 | FFAR1 (0.34) | MRGPRX4PTGER4PTGER2KDRGPBAR1 | |
| SCHEMBL362921 | 0.85 | MRGPRX4 (0.40) | MRGPRX4PTGER4PTGER2PPARGGPBAR1 | |
| SCHEMBL362920 | 0.85 | MRGPRX4 (0.40) | MRGPRX4PTGER4PTGER2PPARGGPBAR1 | |
| SCHEMBL362499 | 0.83 | PPARG (0.32) | PPARGGPBAR1 | |
| SCHEMBL364251 | 0.83 | MEN1 (0.35) | GPBAR1 | |
| SCHEMBL363628 | 0.82 | ADRB1 (0.35) | PTGER4PTGER2KDRGPBAR1P2RX3 | |
| SCHEMBL369888 | 0.82 | KDR (0.38) | MRGPRX4PPARGKDRGPBAR1P2RX3 | |
| SCHEMBL365274 | 0.81 | GPBAR1 (0.46) | MRGPRX4GPBAR1 | |
| SCHEMBL363178 | 0.79 | GPBAR1 (0.51) | PPARGGPBAR1ADRB1ADRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593426-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012007365-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-19 | — | — | WO | disclosed |