Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 2/20 | 0.35 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.35 |
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.34 |
| ▸ | P2RX3 | P56373 | 3/20 | 0.34 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.32 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.32 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.31 |
| ▸ | FNTA | P49354 | 1/20 | 0.31 |
| ▸ | FNTB | P49356 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
| ▸ | FLT1 | P17948 | 1/20 | 0.30 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL370059 | 0.93 | GPBAR1 (0.35) | ADRB1ADRB3GPBAR1P2RX3FFAR1 | |
| SCHEMBL365756 | 0.88 | ADRB3 (0.38) | ADRB1ADRB3GPBAR1P2RX3POLB | |
| SCHEMBL363129 | 0.88 | FFAR1 (0.34) | ADRB1ADRB3GPBAR1PTGER4PTGER2 | |
| SCHEMBL365274 | 0.85 | GPBAR1 (0.46) | GPBAR1POLBTDP1BRD4 | |
| SCHEMBL364646 | 0.83 | P2RX3 (0.37) | ADRB1ADRB3GPBAR1P2RX3PTGER4 | |
| SCHEMBL364647 | 0.83 | P2RX3 (0.37) | ADRB1ADRB3GPBAR1P2RX3PTGER4 | |
| SCHEMBL363394 | 0.82 | MRGPRX4 (0.40) | ADRB1ADRB3GPBAR1P2RX3PTGER4 | |
| SCHEMBL363178 | 0.82 | GPBAR1 (0.51) | ADRB1ADRB3GPBAR1POLBTDP1 | |
| SCHEMBL362064 | 0.81 | CNR1 (0.37) | GPBAR1FFAR1POLBTDP1 | |
| SCHEMBL363089 | 0.81 | GPBAR1 (0.39) | ADRB1ADRB3GPBAR1PTGER4FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593426-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012007365-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-19 | — | — | WO | disclosed |