Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 2/20 | 0.51 |
| ▸ | THRA | P10827 | 1/20 | 0.51 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.51 |
| ▸ | SMPD1 | P17405 | 3/20 | 0.47 |
| ▸ | PLA2G4B | P0C869 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1169240 | 0.84 | MEN1 (0.51) | HSD11B1KMT2AFAAHLMNAALDH1A1 | |
| SCHEMBL1168472 | 0.83 | HSD11B1 (0.49) | HSD11B1KMT2AFAAHALDH1A1 | |
| SCHEMBL1168079 | 0.82 | HSD11B1 (0.45) | HSD11B1NR1H4FAAH | |
| SCHEMBL946220 | 0.75 | HSD11B1 (0.47) | HSD11B1KMT2AFAAH | |
| SCHEMBL2830778 | 0.72 | FAAH (0.36) | HSD11B1KMT2ANR1H4FAAH | |
| SCHEMBL944330 | 0.71 | GPR119 (0.45) | HSD11B1 | |
| SCHEMBL942960 | 0.71 | HSD11B1 (0.47) | HSD11B1FAAHLMNA | |
| SCHEMBL3275288 | 0.70 | NPC1 (0.46) | HSD11B1KMT2ATSHRLMNAALDH1A1 | |
| SCHEMBL28019282 | 0.70 | THRB (0.69) | THRBTHRASMPD1PLA2G4BKMT2A | |
| SCHEMBL8465014 | 0.70 | SMPD1 (0.68) | THRBTHRASMPD1PLA2G4BKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2150526-A2 | N-ADAMANTYL BENZAMIDES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE | High Point Pharmaceuticals, LLC (US) | 2010-02-10 | — | — | EP | claimed |
| WO-2008101914-A2 | N-ADAMANTYL BENZAMIDES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE | HIGH POINT PHARMACEUTICALS, LLC (GB) | 2008-08-28 | — | — | WO | claimed |
| EP-2150526-A2 | N-ADAMANTYL BENZAMIDES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE | High Point Pharmaceuticals, LLC (US) | 2010-02-10 | — | — | EP | disclosed |
| WO-2008101914-A2 | N-ADAMANTYL BENZAMIDES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE | HIGH POINT PHARMACEUTICALS, LLC (GB) | 2008-08-28 | — | — | WO | disclosed |