Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | GRM5 | P41594 | 2/20 | 0.39 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MERTK | Q12866 | 4/20 | 0.38 |
| ▸ | AXL | P30530 | 1/20 | 0.38 |
| ▸ | MET | P08581 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3636972 | 0.85 | PSEN1 (0.40) | KMT2AABCB1ALDH1A1RAB9AMAPT | |
| SCHEMBL3642038 | 0.83 | MKNK1 (0.41) | KMT2AALDH1A1RAB9AMAPTKDM4E | |
| SCHEMBL3636389 | 0.83 | GRM5 (0.39) | ABCB1RAB9AGRM5NPC1CDK9 | |
| SCHEMBL1036142 | 0.81 | PSEN1 (0.54) | — | |
| SCHEMBL3636592 | 0.81 | GRM5 (0.34) | KMT2AKDM4EGRM5GRM1ALOX15 | |
| SCHEMBL3639468 | 0.81 | RAB9A (0.51) | KMT2AALDH1A1RAB9AMAPTKDM4E | |
| SCHEMBL3638385 | 0.80 | NPC1 (0.40) | ALDH1A1RAB9AGAANPC1ALOX15 | |
| SCHEMBL3633453 | 0.78 | NPC1 (0.41) | KMT2AALDH1A1RAB9AKDM4ESMN1; SMN2 | |
| SCHEMBL3638175 | 0.78 | PSEN1 (0.36) | ALDH1A1RAB9AKDM4EGAANPC1 | |
| SCHEMBL3636154 | 0.77 | GRAMD1A (0.50) | MAPTMKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155740-A1 | HETARYLANILINES AS MODULATORS FOR AMYLOID BETA | F. Hoffmann-Roche AG (CH) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008138753-A1 | HETARYLANILINES AS MODULATORS FOR AMYLOID BETA | F. HOFFMANN-LA ROCHE AG (CH) | 2008-11-20 | — | — | WO | disclosed |