Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 7/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 7/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 7/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 7/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 7/20 | 0.40 |
| ▸ | PSENEN | Q9NZ42 | 7/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 5/20 | 0.39 |
| ▸ | ABCG2 | Q9UNQ0 | 5/20 | 0.39 |
| ▸ | GAA | P10253 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3634100 | 0.85 | KMT2A (0.40) | ALOX15ABCB1GAAALDH1A1RAB9A | |
| SCHEMBL3633453 | 0.84 | NPC1 (0.41) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL1039127 | 0.81 | PSEN1 (0.57) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3638385 | 0.80 | NPC1 (0.40) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3639468 | 0.79 | RAB9A (0.51) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3638175 | 0.78 | PSEN1 (0.36) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3636154 | 0.77 | GRAMD1A (0.50) | MAPT | |
| SCHEMBL3634269 | 0.77 | PSEN1 (0.42) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| Hydrochloric Acid SCHEMBL1040464 | 0.76 | PSEN1 (0.42) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3642038 | 0.76 | MKNK1 (0.41) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155740-A1 | HETARYLANILINES AS MODULATORS FOR AMYLOID BETA | F. Hoffmann-Roche AG (CH) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008138753-A1 | HETARYLANILINES AS MODULATORS FOR AMYLOID BETA | F. HOFFMANN-LA ROCHE AG (CH) | 2008-11-20 | — | — | WO | disclosed |