Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM1 | Q13255 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | PBRM1 | Q86U86 | 2/20 | 0.35 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.35 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5616791 | 0.76 | GPR119 (0.37) | GRM1HSD17B10PBRM1NR1I2ADRA1A | |
| SCHEMBL29200964 | 0.73 | GRM1 (0.41) | GRM1HSD17B10CYP2D6CYP3A4PBRM1 | |
| SCHEMBL10353108 | 0.71 | ELANE (0.49) | GRM1HSD17B10OPRK1ALDH1A1KDM4E | |
| SCHEMBL31028552 | 0.71 | ELANE (0.49) | GRM1HSD17B10OPRK1ALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL29659031 | 0.70 | ELANE (0.48) | GRM1HSD17B10OPRK1ALDH1A1KDM4E | |
| SCHEMBL3104046 | 0.69 | L3MBTL1 (0.45) | GRM1CYP2C19ALDH1A1KDM4EPOLB | |
| SCHEMBL2888907 | 0.69 | ALDH1A1 (0.40) | HSD17B10CYP2D6CYP3A4TSHRCYP2C19 | |
| SCHEMBL3904460 | 0.64 | HRH3 (0.39) | GRM1HSD17B10TSHROPRK1HTR2B | |
| SCHEMBL3153895 | 0.64 | ALDH1A1 (0.43) | HSD17B10CYP3A4MAPK1ALDH1A1KDM4E | |
| SCHEMBL3154401 | 0.64 | ALDH1A1 (0.43) | HSD17B10CYP3A4MAPK1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155687-A1 | DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS | Via Pharmaceuticals, Inc. (US) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008141976-A1 | DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS | VIA PHARMACEUTICALS, INC. (US) | 2008-11-27 | — | — | WO | disclosed |