Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 2/20 | 0.56 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.56 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.56 |
| ▸ | PIM1 | P11309 | 1/20 | 0.56 |
| ▸ | CLK2 | P49760 | 1/20 | 0.56 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.56 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.56 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.56 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.56 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.56 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.56 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.56 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.56 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | PARP1 | P09874 | 12/20 | 0.44 |
| ▸ | PARP2 | Q9UGN5 | 9/20 | 0.44 |
| ▸ | CHEK2 | O96017 | 5/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3635473 | 0.83 | AURKB (0.75) | AURKBPRKD3MAP4K4PIM1CLK2 | |
| SCHEMBL3527499 | 0.83 | AURKB (0.45) | AURKBAURKAPARP1PARP2CHEK2 | |
| SCHEMBL3580358 | 0.83 | PARP1 (0.53) | AURKBPIM1PIM3AURKAPARP1 | |
| SCHEMBL3587289 | 0.82 | AURKA (0.56) | AURKBAURKAPARP1PARP2CHEK2 | |
| SCHEMBL3584716 | 0.81 | AURKB (0.47) | AURKBAURKAPARP1PARP2CHEK2 | |
| SCHEMBL3582373 | 0.79 | PARP1 (0.49) | AURKBPIM1PIM3AURKAPARP1 | |
| SCHEMBL3582282 | 0.79 | AURKB (0.61) | AURKBAURKAPARP1CHEK2 | |
| SCHEMBL3576982 | 0.79 | AURKA (0.52) | AURKBAURKAPARP1PARP2CHEK2 | |
| SCHEMBL3580122 | 0.79 | AURKB (0.56) | AURKBAURKAPARP1CHEK2 | |
| SCHEMBL3577227 | 0.78 | AURKA (0.53) | AURKBAURKAPARP1PARP2CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7781596-B1 | Substituted 2-phenylbenzimidazoles, the production thereof and their use | ABBOTT LABORATORIES (US) | 2010-08-24 | — | — | US | disclosed |