SCHEMBL3635669

SCHEMBL3635669

NC=CC[C@@]1(n2ccc(N)nc2=O)O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]1O

nearest known ligand 0.57

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
POLG P54098 1/20 0.46
P2RY2 P41231 12/20 0.46
P2RY4 P51582 7/20 0.42
P2RY6 Q15077 4/20 0.42
POLB P06746 1/20 0.41
POLA1 P09884 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28518605 0.91 POLG (0.47) POLGP2RY2P2RY4P2RY6POLB
SCHEMBL30140872 0.88 POLG (0.49) POLGP2RY2P2RY4P2RY6POLB
SCHEMBL10903450 0.85 POLG (0.45) POLGP2RY2P2RY4P2RY6POLB
SCHEMBL1457065 0.84 P2RY2 (0.54) P2RY2P2RY4P2RY6POLA1
SCHEMBL26102705 0.83 POLG (0.51) POLGP2RY2P2RY4P2RY6POLB
Phosphoric Acid SCHEMBL3635661 0.83 PDE3A (0.43) P2RY2POLBPOLA1
SCHEMBL28633711 0.83 P2RY2 (0.44) POLGP2RY2P2RY4P2RY6POLB
SCHEMBL18394211 0.82 P2RY2 (0.51) POLGP2RY2P2RY4P2RY6POLB
Cyanide SCHEMBL29185226 0.82 P2RY2 (0.51) P2RY2P2RY4P2RY6POLA1
SCHEMBL30697338 0.81 P2RY2 (0.51) POLGP2RY2P2RY4P2RY6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12636304-B2 2026-05-26 US disclosed
EP-4713450-A1 ENGINEERED CONSTRUCTS WITH CASSETTE ARRANGEMENTS FOR INCREASED TRANSCRIPTION OF RNA PAYLOADS Shape Therapeutics Inc. (US) 2026-03-25 EP disclosed
WO-2024238584-A1 ENGINEERED CONSTRUCTS WITH CASSETTE ARRANGEMENTS FOR INCREASED TRANSCRIPTION OF RNA PAYLOADS SHAPE THERAPEUTICS INC. (US) 2024-11-21 WO disclosed
US-20240384261-A1 METHODS, COMPOSITIONS, AND KITS FOR PREPARING SEQUENCING LIBRARY GENEFIRST LIMITED (GB) 2024-11-21 US disclosed
US-20240350621-A1 DOUBLE STRANDED MRNA VACCINES UNIV IOWA RES FOUND (US) 2024-10-24 US disclosed
CN-117795096-A Methods, compositions and kits for preparing sequencing libraries 吉复生物科技有限公司 2024-03-29 CN disclosed
EP-4165179-A2 METHODS OF ENRICHING FOR TARGET NUCLEIC ACID MOLECULES AND USES THEREOF Qiagen Sciences LLC (US) 2023-04-19 EP disclosed
WO-2023014974-A1 DOUBLE STRANDED MRNA VACCINES UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) 2023-02-09 WO disclosed
WO-2022263807-A1 METHODS, COMPOSITIONS, AND KITS FOR PREPARING SEQUENCING LIBRARY GENEFIRST LIMITED (GB) 2022-12-22 WO disclosed
US-20140171635-A1 NOVEL HYDRAZONE-BASED AND OXIME-BASED FLUORESCENT AND CHROMOPHORIC/PRO-FLUORESCENT AND PRO-CHROMOPHORIC REAGENTS AND LINKERS SOLULINK BIOSCIENCES, INC. (US) 2014-06-19 US disclosed
US-8541555-B2 Hydrazone-based and oxime-based fluorescent and chromophoric/pro-fluorescent and pro-chromophoric reagents and linkers SOLULINK BIOSCIENCES, INC. (US) 2013-09-24 US disclosed
EP-2150858-A1 NOVEL HYDRAZONE-BASED AND OXIME-BASED FLUORESCENT AND CHROMOPHORIC/PRO-FLUORESCENT AND PRO-CHROMOPHORIC REAGENTS AND LINKERS Solulink, INC. (US) 2010-02-10 EP disclosed
WO-2008140452-A1 NOVEL HYDRAZONE-BASED AND OXIME-BASED FLUORESCENT AND CHROMOPHORIC/PRO-FLUORESCENT AND PRO-CHROMOPHORIC REAGENTS AND LINKERS SOLULINK, INC. (US) 2008-11-20 WO disclosed
US-20080221343-A1 Labeled biomolecules of chromophore or the fluorophore incorporated into the linker between a reactive linking moiety and a biotin molecule; proteins, nucleic acids AUDAX PRIVATE DEBT LLC, AS AGENT 2008-09-11 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12636304-B2 RNMT, RNGTT, NSUN2 POLG 1469/4885P2RY2 2861/4885P2RY4 3525/4885
US-20080221343-A1 Labeled biomolecules of chromophore or the fluorophore incorporated into the linker between a reactive linking moiety and a biotin molecule; proteins, nucleic acids RRP12, MRPS22, HBG2 POLG 1353/4885P2RY2 2739/4885P2RY4 4510/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.