Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.34 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.34 |
| ▸ | SNCA | P37840 | 5/20 | 0.34 |
| ▸ | GPR52 | Q9Y2T5 | 2/20 | 0.34 |
| ▸ | PNP | P00491 | 1/20 | 0.34 |
| ▸ | GCGR | P47871 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HAT1 | O14929 | 3/20 | 0.33 |
| ▸ | EP300 | Q09472 | 3/20 | 0.33 |
| ▸ | GPR139 | Q6DWJ6 | 2/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL362797 | 0.91 | GCGR (0.39) | BRD4S1PR1S1PR3SNCAGCGR | |
| SCHEMBL362423 | 0.85 | BRD4 (0.35) | BRD4PNPCYP1A2CYP2D6CYP2C9 | |
| SCHEMBL362795 | 0.84 | GPBAR1 (0.36) | BRD4SNCAGCGRMEN1KMT2A | |
| SCHEMBL363191 | 0.83 | ALDH1A1 (0.38) | BRD4S1PR1S1PR3PNPMEN1 | |
| SCHEMBL363587 | 0.82 | GCGR (0.38) | BRD4S1PR1S1PR3GCGRALDH1A1 | |
| SCHEMBL368824 | 0.82 | CREBBP (0.35) | BRD4SNCAGPR52MEN1KMT2A | |
| SCHEMBL368825 | 0.82 | CREBBP (0.35) | BRD4SNCAGPR52MEN1KMT2A | |
| SCHEMBL368826 | 0.82 | CREBBP (0.35) | BRD4SNCAGPR52MEN1KMT2A | |
| SCHEMBL363811 | 0.81 | S1PR1 (0.36) | BRD4S1PR1S1PR3GCGRMEN1 | |
| SCHEMBL361680 | 0.79 | GPBAR1 (0.47) | BRD4S1PR1S1PR3GCGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593426-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-05-22 | — | — | EP | claimed |
| WO-2012007365-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-19 | — | — | WO | claimed |
| EP-2593426-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012007365-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-19 | — | — | WO | disclosed |