Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | F13A1 | P00488 | 1/20 | 0.43 |
| ▸ | TGM2 | P21980 | 1/20 | 0.43 |
| ▸ | TGM1 | P22735 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL648715 | 0.82 | ALDH1A1 (0.57) | ALDH1A1GPR119HTTRAB9AMAPT | |
| SCHEMBL4315879 | 0.82 | LMNA (0.50) | ALDH1A1SMN1; SMN2LMNAHTTKDM4E | |
| SCHEMBL3660279 | 0.81 | ALDH1A1 (0.66) | ALDH1A1SMN1; SMN2HTTKDM4EHSD17B10 | |
| SCHEMBL3636605 | 0.78 | KDM4E (0.55) | ALDH1A1GPR119SMN1; SMN2LMNAHTT | |
| SCHEMBL17807630 | 0.78 | ALDH1A1 (0.85) | ALDH1A1SMN1; SMN2HTTKDM4ECYP3A4 | |
| SCHEMBL2401347 | 0.77 | ALDH1A1 (0.55) | ALDH1A1SMN1; SMN2TSHRF13A1TGM2 | |
| SCHEMBL4312740 | 0.76 | CYP3A4 (0.47) | ALDH1A1GPR119SMN1; SMN2LMNAHTT | |
| SCHEMBL3839998 | 0.75 | GPR119 (0.51) | GPR119RAB9A | |
| SCHEMBL27162489 | 0.73 | ALDH1A1 (0.69) | ALDH1A1SMN1; SMN2LMNAHTTKDM4E | |
| SCHEMBL8512198 | 0.72 | ALDH1A1 (0.91) | ALDH1A1SMN1; SMN2LMNAHTTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2162455-A2 | PYRROLOPYRIDINE COMPOUNDS, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS MEDICAMENTS | Glaxo Group Limited (GB) | 2010-03-17 | — | — | EP | disclosed |
| WO-2008145688-A2 | PYRROLOPYRIDINE COMPOUNDS, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS MEDICAMENTS | GLAXO GROUP LIMITED (GB) | 2008-12-04 | — | — | WO | disclosed |