Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | F13A1 | P00488 | 1/20 | 0.48 |
| ▸ | TGM2 | P21980 | 1/20 | 0.48 |
| ▸ | TGM1 | P22735 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 3/20 | 0.48 |
| ▸ | HTR7 | P34969 | 3/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CCR8 | P51685 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3636605 | 0.84 | KDM4E (0.55) | LMNASMN1; SMN2ALDH1A1HTTKDM4E | |
| SCHEMBL3635894 | 0.82 | ALDH1A1 (0.54) | LMNASMN1; SMN2ALDH1A1HTTKDM4E | |
| SCHEMBL4312740 | 0.82 | CYP3A4 (0.47) | LMNASMN1; SMN2ALDH1A1HTTCYP3A4 | |
| SCHEMBL3413300 | 0.81 | STS (0.57) | ALDH1A1HTTMAPK1CCR8 | |
| SCHEMBL4617335 | 0.76 | SFRP1 (0.54) | — | |
| SCHEMBL4620879 | 0.75 | GPR119 (0.47) | ALDH1A1MEN1KMT2APOLB | |
| SCHEMBL1659340 | 0.74 | MAPK1 (0.83) | LMNASMN1; SMN2ALDH1A1HTTKDM4E | |
| SCHEMBL6193696 | 0.74 | SMN1; SMN2 (0.64) | LMNASMN1; SMN2ALDH1A1HTTKDM4E | |
| SCHEMBL24762021 | 0.74 | MAPK1 (0.56) | LMNASMN1; SMN2HTTKDM4EMAPK1 | |
| SCHEMBL4254479 | 0.74 | MAPK1 (0.67) | LMNASMN1; SMN2ALDH1A1HTTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2069341-A1 | PYRROLO[2, 3-B]PYRIDIN-4-YL-BENZENESULFONAMIDE COMPOUNDS AS IKK2 INHIBITORS | Glaxo Group Limited (GB) | 2009-06-17 | — | — | EP | disclosed |
| WO-2008034860-A1 | PYRROLO[2, 3-B]PYRIDIN-4-YL-BENZENESULFONAMIDE COMPOUNDS AS IKK2 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2008-03-27 | — | — | WO | disclosed |