Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 1/20 | 0.49 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.46 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 6/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 5/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP17A1 | P05093 | 3/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | PLAU | P00749 | 2/20 | 0.40 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9054823 | 0.90 | CYP1A2 (0.52) | HSD17B1HSD17B2NPC1RAB9AGSTP1 | |
| SCHEMBL11723042 | 0.89 | CYP2A6 (0.52) | HSD17B1HSD17B2NPC1RAB9ACASP3 | |
| SCHEMBL7937480 | 0.85 | CYP1A2 (0.46) | HSD17B1HSD17B2NPC1RAB9AGSTP1 | |
| SCHEMBL8734522 | 0.84 | HSD17B1 (0.41) | HSD17B1HSD17B2NPC1RAB9ACASP3 | |
| SCHEMBL5887550 | 0.83 | NPC1 (0.46) | NPC1RAB9ACASP3SENP7CYP1A2 | |
| SCHEMBL5144913 | 0.77 | CYP2A6 (0.50) | HSD17B1HSD17B2NPC1RAB9ACASP3 | |
| SCHEMBL9057774 | 0.76 | CYP1A2 (0.47) | NPC1RAB9AGSTP1CYP1A2CYP2A6 | |
| SCHEMBL8734451 | 0.75 | GAPDH (0.53) | NPC1RAB9ACASP3SENP7CYP3A4 | |
| SCHEMBL8732840 | 0.75 | GAPDH (0.53) | NPC1RAB9ACASP3SENP7CYP3A4 | |
| SCHEMBL9510748 | 0.75 | CYP2A6 (0.48) | HSD17B1HSD17B2NPC1RAB9ACASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6410564-B1 | Naphthyl compounds, intermediates, processes, compositions, and methods | ELI LILLY AND COMPANY | 2002-06-25 | — | — | US | disclosed |
| CN-1163567-A | Method for reducing uterine nutritional effects of tamoxifen and tamoxifen analogues | LILLY CO ELI (US) | 1997-10-29 | — | — | CN | disclosed |
| WO-1996009051-A1 | A METHOD FOR MINIMIZING THE UTEROTROPHIC EFFECT OF TAMOXIFEN AND TAMOXIFEN ANALOGS | ELI LILLY AND COMPANY (US) | 1996-03-28 | — | — | WO | disclosed |
| EP-0703228-A1 | Naphthyl compounds, intermediates, processes, compositions involving them | ELI LILLY AND COMPANY (US) | 1996-03-27 | — | — | EP | disclosed |
| US-5484795-A | Naphthyl compounds, intermediates, processes, compositions, and method of inhibiting restenosis | ELI LILLY AND COMPANY (US) | 1996-01-16 | — | — | US | disclosed |