Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | EBP | Q15125 | 1/20 | 0.48 |
| ▸ | DHCR7 | Q9UBM7 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29957370 | 0.85 | GAA (0.41) | ALDH1A1PKMHTTPOLBKMT2A | |
| SCHEMBL29954812 | 0.83 | ALDH1A1 (0.44) | ALDH1A1KDM4EPKMHTTPOLB | |
| SCHEMBL29952032 | 0.83 | ALDH1A1 (0.47) | ALDH1A1PKMHTTPOLBLMNA | |
| SCHEMBL13041357 | 0.81 | ALDH1A1 (0.50) | ALDH1A1KDM4EHTTPOLBLMNA | |
| SCHEMBL13503961 | 0.80 | LMNA (0.62) | ALDH1A1KDM4EPKMHTTPOLB | |
| SCHEMBL14009157 | 0.77 | ALDH1A1 (0.51) | ALDH1A1KDM4EPKMHTTPOLB | |
| SCHEMBL12169328 | 0.75 | ALDH1A1 (0.63) | ALDH1A1KDM4EPKMHTTPOLB | |
| SCHEMBL11989579 | 0.75 | LMNA (0.56) | ALDH1A1KDM4EPKMHTTPOLB | |
| SCHEMBL28882522 | 0.75 | ALDH1A1 (0.66) | ALDH1A1KDM4EPKMHTTPOLB | |
| SCHEMBL266466 | 0.75 | MEN1 (0.77) | ALDH1A1KDM4EPKMHTTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8765788-B2 | Tricyclic inhibitors of hydroxysteroid dehydrogenases | AMGEN INC. (US) | 2014-07-01 | — | — | US | disclosed |
| US-8765788-B2 | Tricyclic inhibitors of hydroxysteroid dehydrogenases | AMGEN INC. (US) | 2014-07-01 | — | — | US | disclosed |
| US-20100280073-A1 | TRICYCLIC INHIBITORS OF HYDROXYSTEROID DEHYDROGENASES | AMGEN INC. (US) | 2010-11-04 | — | — | US | disclosed |
| US-20100280073-A1 | TRICYCLIC INHIBITORS OF HYDROXYSTEROID DEHYDROGENASES | AMGEN INC. (US) | 2010-11-04 | — | — | US | disclosed |
| EP-2162439-A1 | TRICYCLIC INHIBITORS OF HYDROXYSTEROID DEHYDROGENASES | Amgen Inc. (US) | 2010-03-17 | — | — | EP | disclosed |
| WO-2008156601-A1 | TRICYCLIC INHIBITORS OF HYDROXYSTEROID DEHYDROGENASES | AMGEN INC. (US) | 2008-12-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100280073-A1 | TRICYCLIC INHIBITORS OF HYDROXYSTEROID DEHYDROGENASES | HSD11B1, HSD3B1, HSD17B1 | ALDH1A1 185/4885KDM4E 3240/4885PKM 843/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.