Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | GPR4 | P46093 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL363412 | 0.82 | OPRD1 (0.43) | OPRD1OPRK1GPR4NAMPTGPR119 | |
| SCHEMBL31105872 | 0.81 | ALDH1A1 (0.49) | PKMLMNAALDH1A1MAPTCYP1A2 | |
| SCHEMBL1859418 | 0.80 | PKM (0.51) | PKMLMNAALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL31361627 | 0.79 | ALDH1A1 (0.47) | LMNAALDH1A1MAPTCYP2C19KMT2A | |
| SCHEMBL5543260 | 0.77 | ALDH1A1 (0.41) | LMNAALDH1A1MAPTKMT2AOPRD1 | |
| SCHEMBL19205341 | 0.76 | NR1D1 (0.45) | PKMLMNAALDH1A1MAPTCYP1A2 | |
| SCHEMBL31303377 | 0.73 | MAPT (0.52) | LMNAALDH1A1MAPTKMT2APOLB | |
| SCHEMBL1559337 | 0.73 | ALDH1A1 (0.48) | LMNAALDH1A1MAPTGPR119 | |
| SCHEMBL30817348 | 0.73 | MAPT (0.72) | LMNAALDH1A1MAPTKMT2APOLB | |
| SCHEMBL521187 | 0.73 | PKM (0.53) | PKMLMNAALDH1A1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012007409-A1 | N-SUBSTITUTED PYRROLIDINES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-19 | — | — | WO | disclosed |
| US-20120010235-A1 | N-SUBSTITUTED PYRROLIDINES | CHU XIN-JIE (US) | 2012-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120010235-A1 | N-SUBSTITUTED PYRROLIDINES | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, PKD1, TP53 | PKM 656/4885LMNA 2624/4885ALDH1A1 799/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.