Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOD2 | Q9HC29 | 2/20 | 0.50 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.50 |
| ▸ | CA12 | O43570 | 3/20 | 0.47 |
| ▸ | CA1 | P00915 | 3/20 | 0.47 |
| ▸ | CA2 | P00918 | 3/20 | 0.47 |
| ▸ | CA7 | P43166 | 3/20 | 0.47 |
| ▸ | CA9 | Q16790 | 3/20 | 0.47 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | GAA | P10253 | 5/20 | 0.45 |
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3030334 | 0.83 | NOD2 (0.46) | NOD2NOD1CA12CA1CA2 | |
| SCHEMBL9144581 | 0.83 | CLK1 (0.55) | CA12CA1CA2CA7CA9 | |
| SCHEMBL3637426 | 0.82 | ABCB11 (0.45) | NOD2NOD1CA12CA1CA2 | |
| SCHEMBL3638008 | 0.81 | NOD2 (0.53) | NOD2NOD1GAASMN1; SMN2ALDH1A1 | |
| SCHEMBL3639291 | 0.81 | MMP13 (0.52) | NOD2NOD1MEN1KMT2ALMNA | |
| SCHEMBL3639123 | 0.80 | SRD5A2 (0.61) | NOD2NOD1MEN1KMT2ALMNA | |
| SCHEMBL3675346 | 0.78 | NOD2 (0.43) | NOD2NOD1MEN1KMT2AKDM4E | |
| SCHEMBL3634756 | 0.77 | MAOA (0.45) | NOD2NOD1MEN1KMT2AGAA | |
| SCHEMBL2428965 | 0.76 | MEN1 (0.46) | NOD2NOD1CA12CA1CA2 | |
| SCHEMBL13560471 | 0.76 | CLK1 (0.37) | CA12CA1CA2CA7CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2166856-A1 | CHEMICAL COMPOUNDS | GlaxoSmithKline LLC (US) | 2010-03-31 | — | — | EP | disclosed |
| WO-2008154271-A1 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-12-18 | — | — | WO | disclosed |