Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOD2 | Q9HC29 | 6/20 | 0.43 |
| ▸ | NOD1 | Q9Y239 | 6/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | LGALS8 | O00214 | 1/20 | 0.38 |
| ▸ | LGALS3 | P17931 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | STS | P08842 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2813774 | 0.88 | NOD2 (0.40) | NOD2NOD1MAOAADORA1LGALS8 | |
| SCHEMBL3675353 | 0.85 | KDM4E (0.42) | ADORA1LGALS8LGALS3MEN1KMT2A | |
| SCHEMBL3673992 | 0.80 | HSD11B1 (0.42) | HSD11B1ALDH1A1HPGDL3MBTL1KDM4E | |
| SCHEMBL3637425 | 0.78 | NOD2 (0.50) | NOD2NOD1MAOAMEN1KMT2A | |
| SCHEMBL3639123 | 0.77 | SRD5A2 (0.61) | NOD2NOD1MAOAMEN1KMT2A | |
| SCHEMBL5865527 | 0.77 | STS (0.52) | HSD11B1ALDH1A1HPGDSTSKDM4E | |
| SCHEMBL3634756 | 0.76 | MAOA (0.45) | NOD2NOD1MAOAMEN1KMT2A | |
| SCHEMBL7470558 | 0.75 | NOD2 (0.40) | NOD2NOD1MAOALGALS8LGALS3 | |
| SCHEMBL8613925 | 0.74 | TSHR (0.47) | ADORA1KMT2AHSD11B1ALDH1A1HPGD | |
| SCHEMBL3638008 | 0.73 | NOD2 (0.53) | NOD2NOD1ELANEALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2170072-A1 | FARNESOID X RECEPTOR AGONISTS | GlaxoSmithKline LLC (US) | 2010-04-07 | — | — | EP | disclosed |
| WO-2008157270-A1 | FARNESOID X RECEPTOR AGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-12-24 | — | — | WO | disclosed |