Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | MMP1 | P03956 | 1/20 | 0.50 |
| ▸ | MMP2 | P08253 | 1/20 | 0.50 |
| ▸ | MMP9 | P14780 | 1/20 | 0.50 |
| ▸ | MMP8 | P22894 | 1/20 | 0.50 |
| ▸ | MMP13 | P45452 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | SLC10A6 | Q3KNW5 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | F2 | P00734 | 1/20 | 0.45 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.45 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3104112 | 0.83 | CA1 (0.52) | ALDH1A1CA1CA2MMP1MMP2 | |
| SCHEMBL5201127 | 0.82 | CA1 (0.57) | ALDH1A1CA1CA2MMP1MMP2 | |
| SCHEMBL31120657 | 0.82 | CA1 (0.57) | ALDH1A1CA1CA2MMP1MMP2 | |
| SCHEMBL25353051 | 0.81 | CA1 (0.52) | ALDH1A1CA1CA2MMP1MMP2 | |
| SCHEMBL30449084 | 0.81 | CA1 (0.52) | ALDH1A1CA1CA2MMP1MMP2 | |
| SCHEMBL4172892 | 0.80 | KMT2A (0.56) | ALDH1A1CA1CA2MMP1MMP2 | |
| SCHEMBL12610576 | 0.80 | ALDH1A1 (0.49) | ALDH1A1CA1CA2MMP1MMP2 | |
| SCHEMBL5848761 | 0.80 | ALDH1A1 (0.56) | ALDH1A1CA1CA2MMP1MMP2 | |
| SCHEMBL30299066 | 0.80 | ALDH1A1 (0.46) | ALDH1A1CA1CA2MMP1MMP2 | |
| SCHEMBL6914982 | 0.80 | CA1 (0.51) | ALDH1A1CA1CA2MMP1MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100317697-A1 | Renin Inhibitors | VITAE PHARMACEUTICALS, INC. | 2010-12-16 | — | — | US | disclosed |
| US-20100317697-A1 | Renin Inhibitors | VITAE PHARMACEUTICALS, INC. | 2010-12-16 | — | — | US | disclosed |
| US-20100317697-A1 | Renin Inhibitors | VITAE PHARMACEUTICALS, INC. | 2010-12-16 | — | — | US | disclosed |
| US-20100280005-A1 | Renin Inhibitors | VITAE PHARMACEUTICALS, INC. | 2010-11-04 | — | — | US | disclosed |
| US-20100280005-A1 | Renin Inhibitors | VITAE PHARMACEUTICALS, INC. | 2010-11-04 | — | — | US | disclosed |
| US-20100280005-A1 | Renin Inhibitors | VITAE PHARMACEUTICALS, INC. | 2010-11-04 | — | — | US | disclosed |
| EP-2167609-A1 | RENIN INHIBITORS | Vitae Pharmaceuticals, Inc. (US) | 2010-03-31 | — | — | EP | disclosed |
| WO-2009096996-A1 | RENIN INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-08-06 | — | — | WO | disclosed |
| WO-2009096996-A1 | RENIN INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-08-06 | — | — | WO | disclosed |
| WO-2008124577-A1 | RENIN INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-10-16 | — | — | WO | disclosed |
| WO-2008124577-A1 | RENIN INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-10-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100280005-A1 | Renin Inhibitors | REN, ACE, AGTR1 | ALDH1A1 1651/4885CA1 1575/4885CA2 1426/4885 |
| US-20100317697-A1 | Renin Inhibitors | REN, ACE, SERPINB1 | ALDH1A1 1056/4885CA1 1461/4885CA2 1125/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.