Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | METAP2 | P50579 | 1/20 | 0.34 |
| ▸ | IKBKB | O14920 | 1/20 | 0.34 |
| ▸ | CHUK | O15111 | 1/20 | 0.34 |
| ▸ | PLK4 | O00444 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
| ▸ | LYN | P07948 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
| ▸ | PRKACA | P17612 | 1/20 | 0.34 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27152986 | 0.77 | RXRA (0.45) | TP53MAPK1 | |
| SCHEMBL1978092 | 0.76 | SMN1; SMN2 (0.43) | NPC1RAB9ASMN1; SMN2ATMMETAP2 | |
| SCHEMBL27149405 | 0.74 | KDM4E (0.46) | NPC1RAB9ASMN1; SMN2MAPTMEN1 | |
| SCHEMBL1384288 | 0.72 | KMT2A (0.38) | NPC1RAB9ASMN1; SMN2ATMMETAP2 | |
| SCHEMBL19656316 | 0.72 | MAPT (0.41) | NPC1RAB9ASMN1; SMN2ATMMETAP2 | |
| SCHEMBL27791447 | 0.70 | SLC22A12 (0.36) | ATML3MBTL1SLC22A12MAPTKMT2A | |
| SCHEMBL2186233 | 0.70 | HPGD (0.35) | — | |
| SCHEMBL1128951 | 0.69 | ALDH1A1 (0.50) | NPC1RAB9ASMN1; SMN2PLK4AURKA | |
| SCHEMBL1129154 | 0.69 | ALDH1A1 (0.50) | NPC1RAB9ASMN1; SMN2PLK4AURKA | |
| SCHEMBL21805114 | 0.69 | DYRK1A (0.45) | ROCK1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2176256-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | AstraZeneca AB (SE) | 2010-04-21 | — | — | EP | disclosed |
| WO-2009007751-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |