Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.37 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MAOA | P21397 | 2/20 | 0.32 |
| ▸ | MAOB | P27338 | 2/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9119007 | 0.76 | TP53 (0.42) | KDM4ENPC1L3MBTL1TRPM8ALDH1A1 | |
| SCHEMBL7540735 | 0.74 | NPC1 (0.45) | KDM4ENPC1L3MBTL1ALDH1A1ACHE | |
| SCHEMBL292870 | 0.73 | CHRM2 (0.40) | KDM4ENPC1L3MBTL1ALDH1A1LMNA | |
| SCHEMBL8183218 | 0.72 | VCP (0.42) | KDM4ENPC1ALDH1A1NPSR1MEN1 | |
| SCHEMBL8183221 | 0.71 | SLC6A4 (0.47) | KDM4ENPC1L3MBTL1ALDH1A1LMNA | |
| SCHEMBL581261 | 0.71 | NPC1 (0.41) | NPC1L3MBTL1ALDH1A1ACHE | |
| SCHEMBL8984219 | 0.71 | NPC1 (0.38) | KDM4ENPC1L3MBTL1KCNA5ALDH1A1 | |
| Biphenyl SCHEMBL560539 | 0.69 | TRPM8 (0.43) | KDM4ETRPM8KCNA5ALDH1A1LMNA | |
| SCHEMBL9130854 | 0.67 | ALDH1A1 (0.42) | ALDH1A1ACHEKMT2AMAOAMAOB | |
| SCHEMBL28431861 | 0.67 | ALDH1A1 (0.42) | ALDH1A1ACHEKMT2AMAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10000493-B2 | Process and intermediates for the synthesis of 8-[{1-(3,5-bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds | OPKO HEALTH, INC. (US) | 2018-06-19 | — | — | US | claimed |
| US-9260428-B2 | Process and intermediates for the synthesis of 8-[{1-(3,5-bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds | OPKO HEALTH, INC. (US) | 2016-02-16 | — | — | US | claimed |
| EP-2164832-A1 | PROCESS FOR PREPARING 2-(2-PYRIDYLMETHYL)-SULFINYL-1H-BENZIMIDAZOLES AND THE INTERMEDIATE COMPOUNDS USED THEREIN | Química Sintética, S.A. (ES) | 2010-03-24 | — | — | EP | claimed |
| WO-2008142006-A9 | PROCESS FOR PREPARING 2-(2-PYRIDYLMETHYL)-SULFINYL-1H-BENZIMIDAZOLES AND THE INTERMEDIATE COMPOUNDS USED THEREIN | CHEMO IBÉRICA, S.A. (ES) | 2009-09-24 | — | — | WO | claimed |
| WO-2008142006-A1 | PROCESS FOR PREPARING 2-(2-PYRIDYLMETHYL)-SULFINYL-1H-BENZIMIDAZOLES AND THE INTERMEDIATE COMPOUNDS USED THEREIN | CHEMO IBÉRICA, S.A. (ES) | 2008-11-27 | — | — | WO | claimed |
| US-5688990-A | FORMING CHEMICAL INTERMEDIATES FOR AZETIDINONE COMPOUNDS THAT INHIBIT CHOLESTEROL BIOSYNTHESIS FOR PREVENTION OF ATHEROSCLEROSIS | SHANKAR BANDARPALLE B (US) | 1997-11-18 | — | — | US | claimed |
| EP-0751934-A1 | SUBSTITUTED AZETIDINONE COMPOUNDS USEFUL AS HYPOCHOLESTEROLEMIC AGENTS | SCHERING CORPORATION (US) | 1997-01-08 | — | — | EP | claimed |
| WO-1995026334-A1 | SUBSTITUTED AZETIDINONE COMPOUNDS USEFUL AS HYPOCHOLESTEROLEMIC AGENTS | SCHERING CORPORATION (US) | 1995-10-05 | — | — | WO | claimed |
| US-5455317-A | Homogeneous catalysts for stereoregular olefin polymerization | NORTHWESTERN UNIVERSITY (US) | 1995-10-03 | — | — | US | claimed |
| US-5330948-A | Homogeneous catalysts for stereoregular olefin polymerization | NORTHWESTERN UNIVERSITY (US) | 1994-07-19 | — | — | US | claimed |
| US-5312881-A | Coordination catalysts with metal cyclopentadiene compounds | NORTHWESTERN UNIVERSITY (US) | 1994-05-17 | — | — | US | claimed |
| JP-3133944-A | — | — | None | — | — | JP | disclosed |
| US-10000493-B2 | Process and intermediates for the synthesis of 8-[{1-(3,5-bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds | OPKO HEALTH, INC. (US) | 2018-06-19 | — | — | US | disclosed |
| US-20170008893-A1 | PROCESS AND INTERMEDIATES FOR THE SYNTHESIS OF 8-[-METHYL]-8-PHENYL-1,7-DIAZA-SPIRO[4.5]DECAN-2-ONE COMPOUNDS | TERSERA THERAPEUTICS LLC | 2017-01-12 | — | — | US | disclosed |
| CN-103665038-B | A kind of carbon phosphorus chirality dialkyl phosphine oxide and synthetic method thereof | LIAOCHENG UNIVERSITY (CN) | 2015-11-25 | — | — | CN | disclosed |
| US-5627176-A | MIXED WITH CHOLESTEROL BIOSYNTHESIS INHIBITOR; PREVENTING ATHEROSCLEROSIS | SCHERING CORPORATION (US) | 1997-05-06 | — | — | US | disclosed |
| EP-0751934-A1 | SUBSTITUTED AZETIDINONE COMPOUNDS USEFUL AS HYPOCHOLESTEROLEMIC AGENTS | SCHERING CORPORATION (US) | 1997-01-08 | — | — | EP | disclosed |
| WO-1995026334-A1 | SUBSTITUTED AZETIDINONE COMPOUNDS USEFUL AS HYPOCHOLESTEROLEMIC AGENTS | SCHERING CORPORATION (US) | 1995-10-05 | — | — | WO | disclosed |
| US-5312881-A | Coordination catalysts with metal cyclopentadiene compounds | NORTHWESTERN UNIVERSITY (US) | 1994-05-17 | — | — | US | disclosed |
| JP-H03133944-A | ASYMMETRIC QUATERNARY CARBON COMPOUND, ITS PRODUCTION AND NEW ASYMMETRIC SYNTHESIS USING THE SAME | MITSUI TOATSU CHEM INC | 1991-06-07 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170008893-A1 | PROCESS AND INTERMEDIATES FOR THE SYNTHESIS OF 8-[-METHYL]-8-PHENYL-1,7-DIAZA-SPIRO[4.5]DECAN-2-ONE COMPOUNDS | SLC30A7, KAT7, KAT8 | KDM4E 934/4885NPC1 3670/4885L3MBTL1 4549/4885 |
| US-10000493-B2 | Process and intermediates for the synthesis of 8-[{1-(3,5-bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds | SLC30A7, KAT7, ZNF787 | KDM4E 1144/4885NPC1 3558/4885L3MBTL1 4530/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.