Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | AKT1 | P31749 | 2/20 | 0.39 |
| ▸ | CTSL | P07711 | 2/20 | 0.38 |
| ▸ | CTSB | P07858 | 2/20 | 0.38 |
| ▸ | CTSS | P25774 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.37 |
| ▸ | STS | P08842 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20506813 | 0.79 | ABCB1 (0.46) | ABCB1JAK2JAK1KMT2AMEN1 | |
| SCHEMBL20506814 | 0.79 | ABCB1 (0.46) | ABCB1JAK2JAK1KMT2AMEN1 | |
| SCHEMBL20506783 | 0.79 | ABCB1 (0.46) | ABCB1JAK2JAK1KMT2AMEN1 | |
| SCHEMBL24126275 | 0.77 | AKT1 (0.43) | ABCB1JAK2JAK1KMT2AMEN1 | |
| SCHEMBL8416981 | 0.77 | AKT1 (0.43) | ABCB1JAK2JAK1KMT2AMEN1 | |
| SCHEMBL15707864 | 0.77 | AKT1 (0.43) | ABCB1JAK2JAK1KMT2AMEN1 | |
| SCHEMBL1543215 | 0.77 | ALDH1A1 (0.51) | KMT2AMEN1ALDH1A1L3MBTL1YTHDC1 | |
| SCHEMBL13240737 | 0.77 | ALDH1A1 (0.51) | KMT2AMEN1ALDH1A1L3MBTL1YTHDC1 | |
| SCHEMBL20506828 | 0.77 | ABCB1 (0.46) | ABCB1JAK2JAK1KMT2AAKT1 | |
| Hydrochloric Acid SCHEMBL1543621 | 0.76 | ALDH1A1 (0.50) | KMT2AMEN1ALDH1A1L3MBTL1YTHDC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8691756-B2 | Macrocycles and their uses | NOVARTIS AG (CH) | 2014-04-08 | — | — | US | disclosed |
| US-20130252883-A1 | Macrocycles and Their Uses | NOVARTIS AG (CH) | 2013-09-26 | — | — | US | disclosed |
| US-8476224-B2 | Macrocycles and their uses | NOVARTIS AG (US) | 2013-07-02 | — | — | US | disclosed |
| EP-2170907-A2 | MACROCYCLES AND THEIR USES | Novartis Ag (CH) | 2010-04-07 | — | — | EP | disclosed |
| US-20090186830-A1 | MACROCYCLES AND THEIR USES | NOVARTIS AG (CH) | 2009-07-23 | — | — | US | disclosed |
| WO-2008148754-A2 | MACROCYCLES AND THEIR USES | NOVARTIS AG (CH) | 2008-12-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130252883-A1 | Macrocycles and Their Uses | MRPL21, CLPP, MLEC | ABCB1 287/4885JAK2 522/4885JAK1 3057/4885 |
| US-20090186830-A1 | MACROCYCLES AND THEIR USES | CYP11B2, OAT, CYP27A1 | ABCB1 214/4885JAK2 1129/4885JAK1 3125/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.