SCHEMBL3645017

SCHEMBL3645017

O=C(Nc1ccc(Cl)c(C(F)(F)F)c1)C(Cl)(Cl)Cl

nearest known ligand 0.73

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDR P35968 2/20 0.73
PDK1 Q15118 1/20 0.66
CNR2 P34972 1/20 0.60
GRM4 Q14833 1/20 0.58
TRPV1 Q8NER1 4/20 0.57
NPSR1 Q6W5P4 2/20 0.57
CA1 P00915 1/20 0.57
CA2 P00918 1/20 0.57
CA7 P43166 1/20 0.57
CA9 Q16790 1/20 0.57
MEN1 O00255 1/20 0.57
HTT P42858 1/20 0.57
KMT2A Q03164 1/20 0.57
TMPRSS4 Q9NRS4 1/20 0.57
KCNJ5 P48544 1/20 0.57
KCNJ3 P48549 1/20 0.57
SMN1; SMN2 Q16637 1/20 0.56
LMNA P02545 2/20 0.54
HDAC1 Q13547 1/20 0.53
HDAC8 Q9BY41 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31495074 0.89 KDR (0.76) KDRPDK1CNR2GRM4TRPV1
SCHEMBL8409965 0.88 KDR (0.69) KDRPDK1CNR2GRM4TRPV1
SCHEMBL1943274 0.87 KDR (0.55) KDRPDK1CNR2GRM4TRPV1
SCHEMBL1291336 0.86 KDR (0.71) KDRPDK1CNR2GRM4TRPV1
SCHEMBL29625148 0.86 KDR (0.71) KDRPDK1CNR2GRM4TRPV1
SCHEMBL29625146 0.86 KDR (0.71) KDRPDK1CNR2GRM4TRPV1
SCHEMBL118026 0.85 KDR (1.00) KDRPDK1GRM4TRPV1CA1
SCHEMBL29364392 0.85 KDR (1.00) KDRPDK1GRM4TRPV1CA1
SCHEMBL8407112 0.84 KDR (0.69) KDRPDK1CNR2GRM4TRPV1
SCHEMBL9835641 0.83 KDR (0.78) KDRPDK1CNR2GRM4TRPV1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12623942-B2 Method for extracting salts and temperature- regenerated extracting composition ADIONICS (FR) 2026-05-12 US disclosed
CN-113292128-B Apparatus and method for desalting water by thermal deionization and liquid phase ion extraction 艾迪奥尼克斯公司 2024-07-05 CN disclosed
US-20230382775-A1 METHOD FOR EXTRACTING SALTS AND TEMPERATURE-REGENERATED EXTRACTING COMPOSITION ADIONICS (FR) 2023-11-30 US disclosed
US-11772997-B2 Method for extracting salts and temperature-regenerated extracting composition ADIONICS (FR) 2023-10-03 US disclosed
US-11731933-B2 Device and method for the desalination of water by means of thermal deionisation and liquid-phase ion extraction liquid ADIONICS (FR) 2023-08-22 US disclosed
CN-109641160-B Method for extracting salt and temperature-regenerated extraction composition 艾迪奥尼克斯公司 2022-02-25 CN disclosed
US-20210355076-A1 DEVICE AND METHOD FOR THE DESALINATION OF WATER BY MEANS OF THERMAL DEIONISATION AND LIQUID-PHASE ION EXTRACTION LIQUID ADIONICS (FR) 2021-11-18 US disclosed
CN-113292128-A Apparatus and method for desalination of water by thermal deionization and liquid phase ion extraction 艾迪奥尼克斯公司 2021-08-24 CN disclosed
US-11066356-B2 Device and method for the desalination of water by means of thermal deionisation and liquid-phase ion extraction liquid ADIONICS (FR) 2021-07-20 US disclosed
US-20210214254-A1 METHOD FOR EXTRACTING SALTS AND TEMPERATURE-REGENERATED EXTRACTING COMPOSITION ADIONICS (FR) 2021-07-15 US disclosed
EP-3808425-A1 DEVICE AND METHOD FOR THE DESALINATION OF WATER BY MEANS OF THERMAL DEIONISATION AND LIQUID-PHASE ION EXTRACTION LIQUID ADIONICS (FR) 2021-04-21 EP disclosed
EP-3487597-A1 METHOD FOR EXTRACTING SALTS AND TEMPERATURE-REGENERATED EXTRACTING COMPOSITION Adionics (FR) 2019-05-29 EP disclosed
CN-109641160-A Extract the method for salt and the extracts composition of temperature regeneration 艾迪奥尼克斯公司 2019-04-16 CN disclosed
US-20180009738-A1 DEVICE AND METHOD FOR THE DESALINATION OF WATER BY MEANS OF THERMAL DEIONISATION AND LIQUID-PHASE ION EXTRACTION LIQUID ADIONICS (FR) 2018-01-11 US disclosed
EP-3247677-A1 DEVICE AND METHOD FOR THE DESALINATION OF WATER BY MEANS OF THERMAL DEIONISATION AND LIQUID-PHASE ION EXTRACTION LIQUID ADIONICS (FR) 2017-11-29 EP disclosed
CN-107207288-A Apparatus and method for desalination of water by thermal deionization and liquid phase ion extraction 艾迪奥尼克斯公司 2017-09-26 CN disclosed
US-8445687-B2 Process for the preparation of a RAF kinase inhibitor and intermediates for use in the process CIPLA LIMITED (IN) 2013-05-21 US disclosed
US-20100311980-A1 Process for the Preparation of a RAF Kinase Inhibitor and Intermediates for Use in the Process CIPLA LIMITED (IN) 2010-12-09 US disclosed
EP-2195286-A2 PROCESS FOR THE PREPARATION OF A RAF KINASE INHIBITOR AND INTERMEDIATES FOR USE IN THE PROCESS Cipla Limited (IN) 2010-06-16 EP disclosed
WO-2009034308-A2 PROCESS FOR THE PREPARATION OF A RAF KINASE INHIBITOR AND INTERMEDIATES FOR USE IN THE PROCESS CIPLA LIMITED (IN) 2009-03-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11731933-B2 Device and method for the desalination of water by means of thermal deionisation and liquid-phase ion extraction liquid AQP3, AQP1, AQP4 KDR 863/4885PDK1 3510/4885CNR2 4067/4885
US-20100311980-A1 Process for the Preparation of a RAF Kinase Inhibitor and Intermediates for Use in the Process BRAF, RAF1, ARAF KDR 272/4885PDK1 309/4885CNR2 1095/4885
US-20210355076-A1 DEVICE AND METHOD FOR THE DESALINATION OF WATER BY MEANS OF THERMAL DEIONISATION AND LIQUID-PHASE ION EXTRACTION LIQUID AQP3, AQP1, AQP4 KDR 863/4885PDK1 3510/4885CNR2 4067/4885
US-12623942-B2 Method for extracting salts and temperature- regenerated extracting composition POLQ, NONO, AQP3 KDR 748/4885PDK1 2806/4885CNR2 3624/4885
US-20180009738-A1 DEVICE AND METHOD FOR THE DESALINATION OF WATER BY MEANS OF THERMAL DEIONISATION AND LIQUID-PHASE ION EXTRACTION LIQUID AQP3, AQP1, AQP4 KDR 863/4885PDK1 3510/4885CNR2 4067/4885
US-11066356-B2 Device and method for the desalination of water by means of thermal deionisation and liquid-phase ion extraction liquid AQP3, AQP1, AQP4 KDR 863/4885PDK1 3510/4885CNR2 4067/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.