Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | MAOA | P21397 | 2/20 | 0.46 |
| ▸ | MAOB | P27338 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | SLC6A19 | Q695T7 | 1/20 | 0.40 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6712899 | 0.97 | ALDH1A1 (0.62) | ALDH1A1MAOAMAOBSMN1; SMN2SLC6A19 | |
| Ethylene SCHEMBL233909 | 0.82 | TP53 (0.39) | ALDH1A1MAOAMAOBMAPTNPSR1 | |
| Ethylene SCHEMBL8532842 | 0.81 | LMNA (0.41) | ALDH1A1MAOAMAOBSMN1; SMN2MAPT | |
| Benzaldehyde SCHEMBL11346796 | 0.81 | ALDH1A1 (0.50) | ALDH1A1MAOAMAOBLMNAMEN1 | |
| Ethylene SCHEMBL10571152 | 0.80 | ALDH1A1 (0.91) | ALDH1A1MAOAMAOBSMN1; SMN2SLC6A19 | |
| Ethylene SCHEMBL3648042 | 0.79 | MAOA (0.38) | ALDH1A1MAOAMAOBSMN1; SMN2LMNA | |
| Ethylene SCHEMBL6226363 | 0.79 | LMNA (0.48) | ALDH1A1SMN1; SMN2MAPTLMNAALDH1A3 | |
| SCHEMBL10638856 | 0.79 | TP53 (0.41) | ALDH1A1MAOAMAOBMAPTNPSR1 | |
| Ethylene SCHEMBL8169366 | 0.79 | MAOA (0.44) | ALDH1A1MAOAMAOBSMN1; SMN2CYP1A2 | |
| SCHEMBL569625 | 0.78 | LMNA (0.43) | ALDH1A1MAOAMAOBSMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101835771-A | Aminobenzyl-substituted cyclic sulfones useful as bace inhibitors | NOVARTIS AG | 2010-09-15 | — | — | CN | disclosed |
| EP-2190833-A1 | AMINOBENZYL-SUBSTITUTED CYCLIC SULFONES USEFUL AS BACE INHIBITORS | Novartis Ag (CH) | 2010-06-02 | — | — | EP | disclosed |
| WO-2009024615-A1 | AMINOBENZYL-SUBSTITUTED CYCLIC SULFONES USEFUL AS BACE INHIBITORS | NOVARTIS AG (CH) | 2009-02-26 | — | — | WO | disclosed |
| US-20090054427-A1 | AMINOBENZYL-SUBSTITUTED CYCLIC SULFONES USEFUL AS BACE INHIBITORS | BRIARD EMMANUELLE | 2009-02-26 | — | — | US | disclosed |
| US-4789754-A | PRODUCTION OF CHRYSANTHEMIC ESTERS | NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) | 1988-12-06 | — | — | US | disclosed |
| US-4594355-A | Phenyl ring with a 2,2-dimethylcyclopropanecarboxylic group on ring and a dihalovinyl group in position 3 | NATIONAL RESEARCH DEVELOPMENT CORP. (GB) | 1986-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054427-A1 | AMINOBENZYL-SUBSTITUTED CYCLIC SULFONES USEFUL AS BACE INHIBITORS | BACE2, BACE1, APP | ALDH1A1 2720/4885MAOA 618/4885MAOB 165/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.