Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 6/20 | 0.63 |
| ▸ | MRGPRX4 | Q96LA9 | 5/20 | 0.61 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.60 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.60 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.60 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.60 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | PPARG | P37231 | 1/20 | 0.49 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL364759 | 0.93 | MRGPRX4 (0.64) | SCN9AMRGPRX4HDAC8SCN5AHDAC1 | |
| SCHEMBL371154 | 0.89 | MRGPRX4 (0.62) | SCN9AMRGPRX4HDAC8SCN5AHDAC1 | |
| Diethylamine SCHEMBL16239865 | 0.88 | MRGPRX4 (0.58) | SCN9AMRGPRX4HDAC8SCN5AHDAC1 | |
| SCHEMBL367120 | 0.85 | HDAC8 (0.55) | SCN9AMRGPRX4HDAC8SCN5AHDAC1 | |
| SCHEMBL16240302 | 0.83 | MRGPRX4 (0.61) | SCN9AMRGPRX4HDAC8SCN5AHDAC1 | |
| SCHEMBL365210 | 0.82 | MAOA (0.63) | SCN9ASCN5ASMN1; SMN2KMT2ARAB9A | |
| SCHEMBL366081 | 0.82 | MAOA (0.63) | SCN9ASCN5ASMN1; SMN2KMT2ARAB9A | |
| SCHEMBL16239862 | 0.81 | MRGPRX4 (0.52) | SCN9AMRGPRX4HDAC8SCN5AHDAC1 | |
| SCHEMBL10237079 | 0.81 | SCN9A (0.58) | SCN9AMRGPRX4SCN5A | |
| SCHEMBL679375 | 0.81 | SCN9A (0.58) | SCN9ASCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9096500-B2 | Acyl sulfonamide compounds | PFIZER LIMITED (GB) | 2015-08-04 | — | — | US | disclosed |
| EP-2593428-B1 | N-SULFONYLBENZAMIDES AS INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | PFIZER LTD (GB) | 2014-11-19 | — | — | EP | disclosed |
| EP-2593428-A2 | N-SULFONYLBENZAMIDES AS INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | Pfizer Limited (GB) | 2013-05-22 | — | — | EP | disclosed |
| US-20130109701-A1 | Chemical Compounds | PFIZER LIMITED (GB) | 2013-05-02 | — | — | US | disclosed |
| WO-2012007868-A2 | CHEMICAL COMPOUNDS | PFIZER LIMITED (GB) | 2012-01-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130109701-A1 | Chemical Compounds | SCN1A, SCN1B, SCN7A | SCN9A 16/4885MRGPRX4 458/4885HDAC8 925/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.