Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 7/20 | 0.64 |
| ▸ | HPGD | P15428 | 3/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
| ▸ | SCN9A | Q15858 | 5/20 | 0.57 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
| ▸ | RXRA | P19793 | 1/20 | 0.52 |
| ▸ | RXRB | P28702 | 1/20 | 0.52 |
| ▸ | RXRG | P48443 | 1/20 | 0.52 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.52 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diethylamine SCHEMBL16239865 | 0.94 | MRGPRX4 (0.58) | MRGPRX4HPGDSMN1; SMN2KMT2ASCN9A | |
| SCHEMBL364527 | 0.93 | SCN9A (0.63) | MRGPRX4HPGDSMN1; SMN2KMT2ASCN9A | |
| SCHEMBL16240302 | 0.88 | MRGPRX4 (0.61) | MRGPRX4HPGDSMN1; SMN2KMT2ASCN9A | |
| SCHEMBL371154 | 0.84 | MRGPRX4 (0.62) | MRGPRX4HPGDSMN1; SMN2KMT2ASCN9A | |
| SCHEMBL366081 | 0.82 | MAOA (0.63) | SMN1; SMN2KMT2ASCN9ASCN5ANPC1 | |
| SCHEMBL365210 | 0.82 | MAOA (0.63) | SMN1; SMN2KMT2ASCN9ASCN5ANPC1 | |
| SCHEMBL16319447 | 0.81 | SCN9A (0.53) | MRGPRX4SCN9ASCN5A | |
| SCHEMBL367120 | 0.81 | HDAC8 (0.55) | MRGPRX4SCN9ASCN5AHDAC8HDAC1 | |
| SCHEMBL16239902 | 0.81 | HDAC6 (0.56) | MRGPRX4HPGDSMN1; SMN2KMT2ASCN9A | |
| SCHEMBL365115 | 0.81 | RXRA (0.64) | MRGPRX4SCN9ARXRARXRBRXRG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9096500-B2 | Acyl sulfonamide compounds | PFIZER LIMITED (GB) | 2015-08-04 | — | — | US | disclosed |
| EP-2593428-A2 | N-SULFONYLBENZAMIDES AS INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | Pfizer Limited (GB) | 2013-05-22 | — | — | EP | disclosed |
| US-20130109701-A1 | Chemical Compounds | PFIZER LIMITED (GB) | 2013-05-02 | — | — | US | disclosed |
| WO-2012007868-A2 | CHEMICAL COMPOUNDS | PFIZER LIMITED (GB) | 2012-01-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130109701-A1 | Chemical Compounds | SCN1A, SCN1B, SCN7A | MRGPRX4 458/4885HPGD 3169/4885SMN1; SMN2 236/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.