SCHEMBL3645294

SCHEMBL3645294

O=C[C@@](O)(CO)[C@@H](O)[C@H](O)[C@H](O)CO

nearest known ligand 0.40

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
TDP1 Q9NUW8 1/20 0.39
PDE4A P27815 1/20 0.34
USP2 O75604 1/20 0.32
SLCO1B1 Q9Y6L6 1/20 0.32
AKR1B1 P15121 1/20 0.31
KDM4E B2RXH2 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19512303 1.00 LMNA (0.40) LMNAL3MBTL1TDP1PDE4AUSP2
SCHEMBL16915296 1.00 LMNA (0.40) LMNAL3MBTL1TDP1PDE4AUSP2
SCHEMBL18383123 0.87 AKR1B1 (0.33) LMNAL3MBTL1TDP1AKR1B1
SCHEMBL5496629 0.87 AKR1B1 (0.33) LMNAL3MBTL1TDP1AKR1B1
SCHEMBL10507472 0.84 LMNA (0.37) LMNAL3MBTL1TDP1PDE4AUSP2
SCHEMBL7953192 0.81 PDE4A (0.38) LMNAL3MBTL1TDP1PDE4AUSP2
SCHEMBL28259629 0.80 USP2 (0.35) LMNAL3MBTL1TDP1PDE4AUSP2
SCHEMBL15689286 0.80 LMNA (0.33) LMNAL3MBTL1TDP1PDE4AUSP2
SCHEMBL28085985 0.79 AKR1B1 (0.31) AKR1B1
SCHEMBL11858560 0.78 LMNA (0.43) LMNAL3MBTL1TDP1PDE4AUSP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 74 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4365189-B1 PREVENTION OF DISULFIDE BOND REDUCTION DURING RECOMBINANT PRODUCTION OF POLYPEPTIDES HOFFMANN LA ROCHE (CH) 2025-02-19 EP claimed
CN-112480255-B Prevention of disulfide bond reduction during recombinant production of polypeptides 健泰科生物技术公司 2024-09-27 CN claimed
US-12098211-B2 Prevention of disulfide bond reduction during recombinant production of polypeptides GENENTECH, INC. (US) 2024-09-24 US claimed
US-11987638-B1 Prevention of disulfide bond reduction during recombinant production of polypeptides GENENTECH, INC. (US) 2024-05-21 US claimed
US-20240158527-A1 PREVENTION OF DISULFIDE BOND REDUCTION DURING RECOMBINANT PRODUCTION OF POLYPEPTIDES GENENTECH, INC. (US) 2024-05-16 US claimed
EP-4365189-A2 PREVENTION OF DISULFIDE BOND REDUCTION DURING RECOMBINANT PRODUCTION OF POLYPEPTIDES GENENTECH, INC. (US) 2024-05-08 EP claimed
EP-4335863-A2 PREVENTION OF DISULFIDE BOND REDUCTION DURING RECOMBINANT PRODUCTION OF POLYPEPTIDES Genentech, Inc. (US) 2024-03-13 EP claimed
EP-4245766-A9 PREVENTION OF DISULFIDE BOND REDUCTION DURING RECOMBINANT PRODUCTION OF POLYPEPTIDES Genentech, Inc. (US) 2024-01-24 EP claimed
US-20230383004-A1 PREVENTION OF DISULFIDE BOND REDUCTION DURING RECOMBINANT PRODUCTION OF POLYPEPTIDES GENENTECH, INC. (US) 2023-11-30 US claimed
EP-4245766-A2 PREVENTION OF DISULFIDE BOND REDUCTION DURING RECOMBINANT PRODUCTION OF POLYPEPTIDES Genentech, Inc. (US) 2023-09-20 EP claimed
US-11639395-B2 Prevention of disulfide bond reduction during recombinant production of polypeptides GENENTECH, INC. (US) 2023-05-02 US claimed
US-20210188993-A1 PREVENTION OF DISULFIDE BOND REDUCTION DURING RECOMBINANT PRODUCTION OF POLYPEPTIDES GENENTECH, INC. (US) 2021-06-24 US claimed
WO-2020028616-A1 METHODS FOR MANUFACTURING RECOMBINANT PROTEIN COMPRISING A DISULFIDE BOND LONZA LTD (CH) 2020-02-06 WO claimed
EP-3327026-A1 PREVENTION OF DISULFIDE BOND REDUCTION DURING RECOMBINANT PRODUCTION OF POLYPEPTIDES Genentech, Inc. (US) 2018-05-30 EP claimed
EP-2188302-B1 PREVENTION OF DISULFIDE BOND REDUCTION DURING RECOMBINANT PRODUCTION OF POLYPEPTIDES GENENTECH INC (US) 2017-11-01 EP claimed
US-20140128575-A1 PREVENTION OF DISULFIDE BOND REDUCTION DURING RECOMBINANT PRODUCTION OF POLYPEPTIDES GENENTECH, INC. (US) 2014-05-08 US claimed
EP-2586788-A1 Prevention of disulfide bond reduction during recombinant production of polypeptides Genentech, Inc. (US) 2013-05-01 EP claimed
US-20130017598-A1 PREVENTION OF DISULFIDE BOND REDUCTION DURING RECOMBINANT PRODUCTION OF POLYPEPTIDES GENENTECH, INC. (US) 2013-01-17 US claimed
US-20090053786-A1 Prevention of disulfide bond reduction during recombinant production of polypeptides GENENTECH, INC. 2009-02-26 US claimed
US-12528875-B2 Prevention of disulfide bond reduction during recombinant production of polypeptides GENENTECH, INC. (US) 2026-01-20 US disclosed
US-20260008863-A1 PREVENTION OF DISULFIDE BOND REDUCTION DURING RECOMBINANT PRODUCTION OF POLYPEPTIDES GENENTECH, INC. (US) 2026-01-08 US disclosed
US-12466874-B2 Prevention of protein disulfide bond reduction MEDIMMUNE LLC (US) 2025-11-11 US disclosed
US-20250243291-A1 PREVENTION OF DISULFIDE BOND REDUCTION DURING RECOMBINANT PRODUCTION OF POLYPEPTIDES GENENTECH, INC. (US) 2025-07-31 US disclosed
EP-4365189-B1 PREVENTION OF DISULFIDE BOND REDUCTION DURING RECOMBINANT PRODUCTION OF POLYPEPTIDES HOFFMANN LA ROCHE (CH) 2025-02-19 EP disclosed
CN-119241636-A Prevention of disulfide bond reduction during recombinant production of polypeptides 健泰科生物技术公司 2025-01-03 CN disclosed
US-20240425610-A1 PREVENTION OF DISULFIDE BOND REDUCTION DURING RECOMBINANT PRODUCTION OF POLYPEPTIDES GENENTECH, INC. (US) 2024-12-26 US disclosed
US-12173080-B1 Prevention of disulfide bond reduction during recombinant production of polypeptides GENENTECH, INC. (US) 2024-12-24 US disclosed
US-12145997-B2 Prevention of disulfide bond reduction during recombinant production of polypeptides GENENTECH, INC. (US) 2024-11-19 US disclosed
CN-112480255-B Prevention of disulfide bond reduction during recombinant production of polypeptides 健泰科生物技术公司 2024-09-27 CN disclosed
US-12098211-B2 Prevention of disulfide bond reduction during recombinant production of polypeptides GENENTECH, INC. (US) 2024-09-24 US disclosed
US-20240301080-A1 PREVENTION OF DISULFIDE BOND REDUCTION DURING RECOMBINANT PRODUCTION OF POLYPEPTIDES GENENTECH, INC. (US) 2024-09-12 US disclosed
US-11999791-B2 Prevention of disulfide bond reduction during recombinant production of polypeptides GENENTECH, INC. (US) 2024-06-04 US disclosed
US-11987637-B1 Prevention of disulfide bond reduction during recombinant production of polypeptides GENENTECH, INC. (US) 2024-05-21 US disclosed
US-11987638-B1 Prevention of disulfide bond reduction during recombinant production of polypeptides GENENTECH, INC. (US) 2024-05-21 US disclosed
US-20240158527-A1 PREVENTION OF DISULFIDE BOND REDUCTION DURING RECOMBINANT PRODUCTION OF POLYPEPTIDES GENENTECH, INC. (US) 2024-05-16 US disclosed
US-20240150486-A1 PREVENTION OF DISULFIDE BOND REDUCTION DURING RECOMBINANT PRODUCTION OF POLYPEPTIDES GENENTECH, INC. (US) 2024-05-09 US disclosed
EP-4365189-A2 PREVENTION OF DISULFIDE BOND REDUCTION DURING RECOMBINANT PRODUCTION OF POLYPEPTIDES GENENTECH, INC. (US) 2024-05-08 EP disclosed
US-11976127-B1 Prevention of disulfide bond reduction during recombinant production of polypeptides GENENTECH, INC. (US) 2024-05-07 US disclosed
US-20240132612-A1 PREVENTION OF DISULFIDE BOND REDUCTION DURING RECOMBINANT PRODUCTION OF POLYPEPTIDES GENENTECH, INC. (US) 2024-04-25 US disclosed
EP-4335863-A2 PREVENTION OF DISULFIDE BOND REDUCTION DURING RECOMBINANT PRODUCTION OF POLYPEPTIDES Genentech, Inc. (US) 2024-03-13 EP disclosed
EP-4245766-A9 PREVENTION OF DISULFIDE BOND REDUCTION DURING RECOMBINANT PRODUCTION OF POLYPEPTIDES Genentech, Inc. (US) 2024-01-24 EP disclosed
US-20230383004-A1 PREVENTION OF DISULFIDE BOND REDUCTION DURING RECOMBINANT PRODUCTION OF POLYPEPTIDES GENENTECH, INC. (US) 2023-11-30 US disclosed
US-20230365704-A1 PREVENTION OF DISULFIDE BOND REDUCTION DURING RECOMBINANT PRODUCTION OF POLYPEPTIDES GENENTECH, INC. (US) 2023-11-16 US disclosed
EP-4245766-A2 PREVENTION OF DISULFIDE BOND REDUCTION DURING RECOMBINANT PRODUCTION OF POLYPEPTIDES Genentech, Inc. (US) 2023-09-20 EP disclosed
EP-4219522-A2 PREVENTION OF DISULFIDE BOND REDUCTION DURING RECOMBINANT PRODUCTION OF POLYPEPTIDES Genentech, Inc. (US) 2023-08-02 EP disclosed
US-11639395-B2 Prevention of disulfide bond reduction during recombinant production of polypeptides GENENTECH, INC. (US) 2023-05-02 US disclosed
EP-3597659-B1 PREVENTION OF DISULFIDE BOND REDUCTION DURING RECOMBINANT PRODUCTION OF POLYPEPTIDES GENENTECH INC (US) 2023-03-01 EP disclosed
US-20220098282-A1 PREVENTION OF PROTEIN DISULFIDE BOND REDUCTION MEDIMMUNE LLC 2022-03-31 US disclosed
US-11078294-B2 Prevention of disulfide bond reduction during recombinant production of polypeptides GENENTECH, INC. (US) 2021-08-03 US disclosed
US-20210188993-A1 PREVENTION OF DISULFIDE BOND REDUCTION DURING RECOMBINANT PRODUCTION OF POLYPEPTIDES GENENTECH, INC. (US) 2021-06-24 US disclosed
US-20210095040-A1 PREVENTION OF DISULFIDE BOND REDUCTION DURING RECOMBINANT PRODUCTION OF POLYPEPTIDES GENENTECH, INC. (US) 2021-04-01 US disclosed
CN-112480255-A Prevention of disulfide bond reduction during recombinant production of polypeptides 健泰科生物技术公司 2021-03-12 CN disclosed
US-10906986-B2 Prevention of disulfide bond reduction during recombinant production of polypeptides GENENTECH, INC. (US) 2021-02-02 US disclosed
US-20200347145-A1 PREVENTION OF DISULFIDE BOND REDUCTION DURING RECOMBINANT PRODUCTION OF POLYPEPTIDES GENENTECH, INC. (US) 2020-11-05 US disclosed
US-10808037-B1 Prevention of disulfide bond reduction during recombinant production of polypeptides GENENTECH, INC. (US) 2020-10-20 US disclosed
US-20200317801-A1 PREVENTION OF DISULFIDE BOND REDUCTION DURING RECOMBINANT PRODUCTION OF POLYPEPTIDES GENENTECH, INC. (US) 2020-10-08 US disclosed
US-10759866-B2 Prevention of disulfide bond reduction during recombinant production of polypeptides GENENTECH, INC. (US) 2020-09-01 US disclosed
WO-2020028616-A1 METHODS FOR MANUFACTURING RECOMBINANT PROTEIN COMPRISING A DISULFIDE BOND LONZA LTD (CH) 2020-02-06 WO disclosed
EP-3327026-B1 PREVENTION OF DISULFIDE BOND REDUCTION DURING RECOMBINANT PRODUCTION OF POLYPEPTIDES GENENTECH INC (US) 2019-08-21 EP disclosed
US-20190135935-A1 PREVENTION OF DISULFIDE BOND REDUCTION DURING RECOMBINANT PRODUCTION OF POLYPEPTIDES GENENTECH, INC. (US) 2019-05-09 US disclosed
US-20190112357-A1 PREVENTION OF PROTEIN DISULFIDE BOND REDUCTION MEDIMMUNE LLC 2019-04-18 US disclosed
EP-3454890-A1 PREVENTION OF PROTEIN DISULFIDE BOND REDUCTION MedImmune, LLC (US) 2019-03-20 EP disclosed
EP-3327026-A1 PREVENTION OF DISULFIDE BOND REDUCTION DURING RECOMBINANT PRODUCTION OF POLYPEPTIDES Genentech, Inc. (US) 2018-05-30 EP disclosed
EP-2586788-B1 Prevention of disulfide bond reduction during recombinant production of polypeptides GENENTECH INC (US) 2017-11-29 EP disclosed
WO-2017196810-A1 PREVENTION OF PROTEIN DISULFIDE BOND REDUCTION MEDIMMUNE, LLC (US) 2017-11-16 WO disclosed
US-20170313780-A1 PREVENTION OF DISULFIDE BOND REDUCTION DURING RECOMBINANT PRODUCTION OF POLYPEPTIDES GENENTECH, INC. (US) 2017-11-02 US disclosed
EP-2188302-B1 PREVENTION OF DISULFIDE BOND REDUCTION DURING RECOMBINANT PRODUCTION OF POLYPEPTIDES GENENTECH INC (US) 2017-11-01 EP disclosed
US-20140128575-A1 PREVENTION OF DISULFIDE BOND REDUCTION DURING RECOMBINANT PRODUCTION OF POLYPEPTIDES GENENTECH, INC. (US) 2014-05-08 US disclosed
US-8574869-B2 Prevention of disulfide bond reduction during recombinant production of polypeptides GENENTECH, INC. (US) 2013-11-05 US disclosed
EP-2586788-A1 Prevention of disulfide bond reduction during recombinant production of polypeptides Genentech, Inc. (US) 2013-05-01 EP disclosed
US-20130017598-A1 PREVENTION OF DISULFIDE BOND REDUCTION DURING RECOMBINANT PRODUCTION OF POLYPEPTIDES GENENTECH, INC. (US) 2013-01-17 US disclosed
EP-2188302-A2 PREVENTION OF DISULFIDE BOND REDUCTION DURING RECOMBINANT PRODUCTION OF POLYPEPTIDES Genentech, Inc. (US) 2010-05-26 EP disclosed
US-20090053786-A1 Prevention of disulfide bond reduction during recombinant production of polypeptides GENENTECH, INC. 2009-02-26 US disclosed
WO-2009009523-A2 PREVENTION OF DISULFIDE BOND REDUCTION DURING RECOMBINANT PRODUCTION OF POLYPEPTIDES GENENTECH, INC. (US) 2009-01-15 WO disclosed
WO-2009009523-A2 PREVENTION OF DISULFIDE BOND REDUCTION DURING RECOMBINANT PRODUCTION OF POLYPEPTIDES GENENTECH, INC. (US) 2009-01-15 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12528875-B2 Prevention of disulfide bond reduction during recombinant production of polypeptides TXN, TXNRD1, TXNRD3 LMNA 4607/4885L3MBTL1 3552/4885TDP1 2622/4885
US-20260008863-A1 PREVENTION OF DISULFIDE BOND REDUCTION DURING RECOMBINANT PRODUCTION OF POLYPEPTIDES TXN, TXNRD1, TXNRD3 LMNA 4610/4885L3MBTL1 3594/4885TDP1 2949/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.