Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.67 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.67 |
| ▸ | TSHR | P16473 | 3/20 | 0.58 |
| ▸ | RXRA | P19793 | 2/20 | 0.49 |
| ▸ | RXRB | P28702 | 2/20 | 0.49 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.46 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.45 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.44 |
| ▸ | PNMT | P11086 | 1/20 | 0.44 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | PTPRC | P08575 | 1/20 | 0.43 |
| ▸ | PTPRG | P23470 | 1/20 | 0.43 |
| ▸ | RXRG | P48443 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11828147 | 0.84 | PNMT (0.60) | SMN1; SMN2NPSR1TSHRPNMTALDH1A1 | |
| SCHEMBL3301733 | 0.80 | PNMT (0.56) | SMN1; SMN2NPSR1HPGDPNMTALDH1A1 | |
| SCHEMBL3368099 | 0.79 | TSHR (0.54) | SMN1; SMN2NPSR1TSHRRXRARXRB | |
| SCHEMBL27873323 | 0.78 | SMN1; SMN2 (0.50) | SMN1; SMN2NPSR1TSHRNR4A2SLC22A12 | |
| SCHEMBL1042000 | 0.75 | PNMT (0.55) | SMN1; SMN2NPSR1TSHRPNMTALDH1A1 | |
| SCHEMBL27873445 | 0.75 | TSHR (0.61) | SMN1; SMN2NPSR1TSHRPNMTALDH1A1 | |
| SCHEMBL4770907 | 0.74 | SMN1; SMN2 (0.52) | SMN1; SMN2NPSR1TSHRRXRARXRB | |
| SCHEMBL69041 | 0.74 | TSHR (1.00) | TSHRHPGDSRD5A2ALDH1A1ALOX15 | |
| SCHEMBL11464000 | 0.74 | TSHR (0.50) | SMN1; SMN2TSHRNR4A2SRD5A2ALDH1A1 | |
| SCHEMBL6248551 | 0.74 | TSHR (0.69) | TSHRSRD5A2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593427-A1 | SULFONAMIDE DERIVATIVES AS NAV1.7 INHIBITORS FOR THE TREATMENT OF PAIN | Pfizer Limited (GB) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012007883-A1 | SULFONAMIDE DERIVATIVES AS NAV1.7 INHIBITORS FOR THE TREATMENT OF PAIN | PFIZER LIMITED (GB) | 2012-01-19 | — | — | WO | disclosed |