Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | CISD1 | Q9NZ45 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | KDM6B | O15054 | 1/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.38 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3646867 | 0.82 | ALDH1A1 (0.44) | ALDH1A1SMN1; SMN2HSD17B10MAPTGAA | |
| Hydrochloric Acid SCHEMBL11276211 | 0.81 | ALDH1A1 (0.43) | ALDH1A1SMN1; SMN2HSD17B10MAPTGAA | |
| SCHEMBL11274736 | 0.79 | HCAR3 (0.57) | PTGER4ALDH1A1SMN1; SMN2MAPTGAA | |
| SCHEMBL11073590 | 0.79 | ALDH1A1 (0.37) | ALDH1A1SMN1; SMN2HSD17B10MAPTGAA | |
| SCHEMBL11271074 | 0.78 | HPGD (0.48) | ALDH1A1SMN1; SMN2HSD17B10MAPTGAA | |
| Hydrochloric Acid SCHEMBL11264387 | 0.77 | HPGD (0.47) | ALDH1A1SMN1; SMN2HSD17B10MAPTGAA | |
| SCHEMBL11209782 | 0.77 | ALDH1A1 (0.44) | ALDH1A1HSD17B10MAPTGAAKDM4E | |
| SCHEMBL11276126 | 0.76 | HSD17B3 (0.44) | ALDH1A1HSD17B10MAPTHPGDALOX15 | |
| Hydrochloric Acid SCHEMBL11212030 | 0.75 | ALDH1A1 (0.43) | ALDH1A1SMN1; SMN2HSD17B10MAPTGAA | |
| SCHEMBL12959658 | 0.72 | PRSS1 (0.41) | CISD1TLR8PRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2197872-A1 | PHENYLISOQUINOLINE AND PHENYLQUINAZOLINE DERIVATIVES FOR THE TREATMENT OF BONE DISEASES | Novartis Ag (CH) | 2010-06-23 | — | — | EP | disclosed |
| US-20090074791-A1 | Phenylisoquinoline and Phenylquinazoline Derivatives | BEERLI RENE | 2009-03-19 | — | — | US | disclosed |
| WO-2009027475-A1 | PHENYLISOQUINOLINE AND PHENYLQUINAZOLINE DERIVATIVES FOR THE TREATMENT OF BONE DISEASES | NOVARTIS AG (CH) | 2009-03-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090074791-A1 | Phenylisoquinoline and Phenylquinazoline Derivatives | CAMK1D, CAMK1, PHPT1 | PTGER4 1325/4885ALDH1A1 4385/4885SMN1; SMN2 4657/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.