Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 9/20 | 0.52 |
| ▸ | KMO | O15229 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.45 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 2/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | CPS1 | P31327 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17996051 | 0.87 | P2RX3 (0.55) | SCN9AP2RX3SLC6A4ABL1CPS1 | |
| SCHEMBL21274571 | 0.83 | HPGD (0.52) | SCN9AP2RX3SLC6A4CPS1 | |
| SCHEMBL16319184 | 0.83 | KMO (0.56) | SCN9AKMOHSP90AA1P2RX3SCN5A | |
| SCHEMBL23386692 | 0.82 | XDH (0.51) | P2RX3CPS1TDP1 | |
| SCHEMBL3139349 | 0.81 | HPGD (0.47) | SCN9AP2RX3SLC6A4ABL1TDP1 | |
| SCHEMBL16319605 | 0.80 | SCN9A (0.76) | SCN9ASCN5A | |
| SCHEMBL1554929 | 0.79 | CPS1 (0.61) | CPS1 | |
| SCHEMBL26965756 | 0.78 | ALDH1A1 (0.48) | P2RX3CPS1 | |
| SCHEMBL19898600 | 0.77 | MRGPRX4 (0.46) | KMOABL1 | |
| SCHEMBL22407112 | 0.77 | CHEK2 (0.42) | SCN9AKMOHSP90AA1HTR2ASLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593427-B1 | SULFONAMIDE DERIVATIVES AS NAV1.7 INHIBITORS FOR THE TREATMENT OF PAIN | PFIZER LTD (GB) | 2014-12-24 | — | — | EP | disclosed |
| EP-2593427-A1 | SULFONAMIDE DERIVATIVES AS NAV1.7 INHIBITORS FOR THE TREATMENT OF PAIN | Pfizer Limited (GB) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012007883-A1 | SULFONAMIDE DERIVATIVES AS NAV1.7 INHIBITORS FOR THE TREATMENT OF PAIN | PFIZER LIMITED (GB) | 2012-01-19 | — | — | WO | disclosed |