Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3650309 | 0.83 | KMT2A (0.50) | NPC1MEN1KMT2AALDH1A1GAA | |
| SCHEMBL3658726 | 0.83 | CYP1A2 (0.44) | NPC1POLBMAPTKDM4EMAPK1 | |
| Trifluoroacetic Acid SCHEMBL3655787 | 0.82 | MLYCD (0.46) | NPC1POLBMAPTKDM4EMEN1 | |
| SCHEMBL3650124 | 0.81 | HSP90AA1 (0.50) | NPC1MAPTKDM4EMAPK1MEN1 | |
| SCHEMBL3655153 | 0.81 | NPC1 (0.43) | NPC1MAPTKDM4EMEN1KMT2A | |
| Trifluoroacetic Acid SCHEMBL3653647 | 0.80 | KMT2A (0.45) | NPC1MEN1KMT2AALDH1A1GAA | |
| SCHEMBL3658289 | 0.79 | KMT2A (0.45) | NPC1MAPTMEN1KMT2AALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL3651075 | 0.79 | CYP1A2 (0.40) | NPC1POLBMAPTKDM4EMEN1 | |
| Trifluoroacetic Acid SCHEMBL3657556 | 0.79 | HSP90AA1 (0.45) | NPC1POLBMAPTKDM4EMEN1 | |
| SCHEMBL3652477 | 0.78 | ESR1 (0.45) | NPC1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2212282-A1 | SUBSTITUTED N-PHENYL-BIPYRROLIDINE CARBOXAMIDES AND THERAPEUTIC USE THEREOF | Sanofi-Aventis (FR) | 2010-08-04 | — | — | EP | disclosed |
| WO-2009052065-A1 | SUBSTITUTED N-PHENYL-BIPYRROLIDINE CARBOXAMIDES AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2009-04-23 | — | — | WO | disclosed |