Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | TACR1 | P25103 | 9/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.40 |
| ▸ | ATXN2 | Q99700 | 1/20 | 0.40 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.39 |
| ▸ | TAOK3 | Q9H2K8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3658891 | 0.83 | SMN1; SMN2 (0.46) | HRH3TACR1TSHRMAPTHTT | |
| SCHEMBL3661150 | 0.77 | MGLL (0.44) | TSHRENPP2 | |
| SCHEMBL5196730 | 0.70 | HDAC3 (0.46) | TSHRMAPK1HTTSMN1; SMN2 | |
| SCHEMBL15544614 | 0.69 | CYP2D6 (0.39) | KITL3MBTL1 | |
| SCHEMBL3984899 | 0.69 | OPRM1 (0.41) | TACR1KITMAPTMAPK1HTT | |
| SCHEMBL6174943 | 0.69 | RORC (0.38) | KITMAPTMAPK1HTT | |
| SCHEMBL3661079 | 0.69 | PRMT5 (0.50) | TSHRSMN1; SMN2L3MBTL1 | |
| SCHEMBL14279760 | 0.68 | ANO1 (0.47) | TACR1TSHRMAPTHTTSMN1; SMN2 | |
| SCHEMBL6229595 | 0.68 | HTT (0.49) | TSHRKITMAPTMAPK1HTT | |
| SCHEMBL20571140 | 0.68 | SMN1; SMN2 (0.41) | MAPTHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238135-A1 | NAPHTHYRIDIN-2(1H) -ONE COMPOUNDS USEFUL AS ANTIBACTERIALS | Glaxo Group Limited (GB) | 2010-10-13 | — | — | EP | disclosed |
| WO-2009090222-A1 | NAPHTHYRIDIN-2(1H) -ONE COMPOUNDS USEFUL AS ANTIBACTERIALS | GLAXO GROUP LIMITED (GB) | 2009-07-23 | — | — | WO | disclosed |