Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.94 |
| ▸ | HMGCR | P04035 | 1/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | ACLY | P53396 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | SLC13A5 | Q86YT5 | 4/20 | 0.42 |
| ▸ | CPT2 | P23786 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL8400312 | 1.00 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL4819877 | 1.00 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL3659 | 1.00 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL11211773 | 1.00 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL9070187 | 1.00 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL2593972 | 1.00 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL4372285 | 1.00 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL116215 | 1.00 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL11519286 | 1.00 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL2411531 | 1.00 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117124459-A | Preparation method of stain-resistant antibacterial lightweight concrete external wall panel | 南昌工学院 | 2023-11-28 | — | — | CN | claimed |
| CN-107522929-A | A kind of anlistatig high polymer material | 南通成山高分子材料有限公司 | 2017-12-29 | — | — | CN | claimed |
| CN-105542520-B | It is a kind of for antirust coat of base steel material and preparation method thereof | 上海底特精密紧固件股份有限公司 | 2017-10-24 | — | — | CN | claimed |
| CN-106818791-A | A kind of emamectin-benzoate mite killing suspending agent of eugenol synergy and preparation method thereof | 孙华飞 | 2017-06-13 | — | — | CN | claimed |
| CN-106631408-A | Pest-resistant high-yielding and high-efficiency corn fertilizer and preparation method thereof | 新昌县老五农产品专业合作社 | 2017-05-10 | — | — | CN | claimed |
| CN-106635495-A | Antibacterial hand-protective hand-wash liquid detergent and preparation method thereof | 苏州纳贝通环境科技有限公司 | 2017-05-10 | — | — | CN | claimed |
| CN-117124459-A | Preparation method of stain-resistant antibacterial lightweight concrete external wall panel | 南昌工学院 | 2023-11-28 | — | — | CN | disclosed |
| CN-107522929-A | A kind of anlistatig high polymer material | 南通成山高分子材料有限公司 | 2017-12-29 | — | — | CN | disclosed |
| CN-106818791-A | A kind of emamectin-benzoate mite killing suspending agent of eugenol synergy and preparation method thereof | 孙华飞 | 2017-06-13 | — | — | CN | disclosed |
| US-7153649-B2 | Treatment of congestive heart failure | VASOGEN IRELAND LIMITED (IE) | 2006-12-26 | — | — | US | disclosed |
| US-20060193835-A1 | Treatment of congestive heart failure | SMITH ELDON R | 2006-08-31 | — | — | US | disclosed |
| EP-1267897-B1 | TREATMENT OF CONGESTIVE HEART FAILURE BY PRETREATED AUTOLOGOUS BLOOD | VASOGEN IRELAND LTD (IE) | 2004-11-10 | — | — | EP | disclosed |
| US-6572895-B2 | Treating an aliquot of patient's blood ex vivo with a stressor selected from temperature above or below body temperature, an electromagnetic emission and an oxidative environment, followed by administering back into patient | VASOGEN IRELAND LIMITED (IE) | 2003-06-03 | — | — | US | disclosed |
| US-20030044390-A1 | Treatment of congestive heart failure | VASOGEN IRELAND LIMITED (IE) | 2003-03-06 | — | — | US | disclosed |
| EP-1267897-A1 | TREATMENT OF CONGESTIVE HEART FAILURE BY PRETREATED AUTOLOGOUS BLOOD | Vasogen Ireland Limited (IE) | 2003-01-02 | — | — | EP | disclosed |
| US-20020051766-A1 | Treatment of congestive heart failure | VASOGEN IRELAND LIMITED (IE) | 2002-05-02 | — | — | US | disclosed |
| WO-2001052870-A1 | TREATMENT OF CONGESTIVE HEART FAILURE BY PRETREATED AUTOLOGOUS BLOOD | VASOGEN IRELAND LIMITED (IE) | 2001-07-26 | — | — | WO | disclosed |