Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR3 | Q99500 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 5/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL366209 | 0.90 | HPGD (0.46) | P4HTMKDM4EALDH1A1LMNAMAPT | |
| SCHEMBL366060 | 0.85 | LMNA (0.42) | TSHRP4HTMKDM4EALDH1A1NAMPT | |
| SCHEMBL366382 | 0.85 | HPGD (0.38) | POLBP4HTMKDM4EALDH1A1LMNA | |
| SCHEMBL365440 | 0.83 | MAPT (0.41) | KDM4EALDH1A1HSD17B10LMNAHTT | |
| SCHEMBL365602 | 0.81 | ALDH1A1 (0.41) | S1PR3TSHRPOLBKDM4EALDH1A1 | |
| SCHEMBL366252 | 0.81 | ALDH1A1 (0.39) | KDM4EALDH1A1HSD17B10LMNAHTT | |
| SCHEMBL366977 | 0.79 | SCN9A (0.46) | KDM4EALDH1A1MAPTHPGDKMT2A | |
| SCHEMBL364815 | 0.79 | PTPN1 (0.39) | KDM4EALDH1A1HSD17B10LMNAHTT | |
| SCHEMBL365519 | 0.74 | KMT2A (0.45) | POLBMAPTHPGDKMT2A | |
| SCHEMBL366210 | 0.74 | HPGD (0.47) | POLBP4HTMKDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012007007-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | claimed |
| WO-2012007007-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | disclosed |