Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | NAMPT | P43490 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.37 |
| ▸ | PTAFR | P25105 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL366210 | 0.89 | HPGD (0.47) | LMNAKDM4EALDH1A1KMT2AP4HTM | |
| SCHEMBL366059 | 0.85 | S1PR3 (0.38) | LMNAKDM4EHTTTSHRNAMPT | |
| SCHEMBL366383 | 0.84 | HPGD (0.40) | LMNAKDM4EHTTKMT2AP4HTM | |
| SCHEMBL365441 | 0.83 | ALDH1A1 (0.40) | LMNAKDM4EALDH1A1HPGD | |
| SCHEMBL365603 | 0.81 | TSHR (0.38) | LMNAKDM4EHTTTSHRNAMPT | |
| SCHEMBL366253 | 0.80 | ALDH1A1 (0.45) | LMNAKDM4EHTTTSHRALDH1A1 | |
| SCHEMBL366978 | 0.78 | SCN9A (0.45) | KDM4EALDH1A1HPGD | |
| SCHEMBL364816 | 0.78 | ALDH1A1 (0.41) | KDM4EALDH1A1HPGD | |
| SCHEMBL365520 | 0.73 | POLB (0.46) | LMNAKDM4EHTTALDH1A1KMT2A | |
| SCHEMBL367569 | 0.71 | SRC (0.46) | LMNAKDM4EHTTALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012007007-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | claimed |
| WO-2012007007-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | disclosed |