Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL365932 | 0.89 | ALDH1A1 (0.48) | MAPTHPGDALDH1A1PTGER4FLT1 | |
| SCHEMBL366383 | 0.84 | HPGD (0.40) | POLBKMT2AMEN1MAPTHPGD | |
| SCHEMBL366978 | 0.84 | SCN9A (0.45) | HPGDKDM4EALDH1A1 | |
| SCHEMBL365519 | 0.83 | KMT2A (0.45) | POLBKMT2AMEN1MAPTHPGD | |
| SCHEMBL365441 | 0.82 | ALDH1A1 (0.40) | HPGDEGFRKDM4EALDH1A1LMNA | |
| SCHEMBL366253 | 0.79 | ALDH1A1 (0.45) | KMT2AMEN1MAPTHPGDKDM4E | |
| SCHEMBL364821 | 0.79 | ADAM17 (0.41) | POLBKMT2AMEN1MAPTHPGD | |
| SCHEMBL366210 | 0.78 | HPGD (0.47) | POLBKMT2AMEN1MAPTHPGD | |
| SCHEMBL364816 | 0.77 | ALDH1A1 (0.41) | HPGDKDM4EALDH1A1PTGER4 | |
| SCHEMBL367569 | 0.77 | SRC (0.46) | POLBKMT2AMAPTHPGDEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012007007-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | claimed |
| WO-2012007007-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | disclosed |