Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | PTGER4 | P35408 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 4/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL366210 | 0.93 | HPGD (0.47) | HPGDPTGER4LMNAPOLBKDM4E | |
| SCHEMBL365441 | 0.86 | ALDH1A1 (0.40) | HPGDLMNAKDM4EHDAC6SMN1; SMN2 | |
| SCHEMBL366060 | 0.84 | LMNA (0.42) | HPGDLMNAKDM4EP4HTMMEN1 | |
| SCHEMBL365520 | 0.84 | POLB (0.46) | HPGDPTGER4LMNAPOLBKDM4E | |
| SCHEMBL366382 | 0.84 | HPGD (0.38) | HPGDPTGER4LMNAPOLBTHRB | |
| SCHEMBL366253 | 0.83 | ALDH1A1 (0.45) | HPGDPTGER4LMNAKDM4EMEN1 | |
| SCHEMBL366978 | 0.81 | SCN9A (0.45) | HPGDKDM4E | |
| SCHEMBL364816 | 0.81 | ALDH1A1 (0.41) | HPGDPTGER4KDM4EAGTR1 | |
| SCHEMBL367074 | 0.81 | LMNA (0.39) | PTGER4LMNAPOLBTHRBMEN1 | |
| SCHEMBL365932 | 0.78 | ALDH1A1 (0.48) | HPGDPTGER4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012007007-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | claimed |
| WO-2012007007-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | disclosed |