Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | NCOA3 | Q9Y6Q9 | 2/20 | 0.39 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.39 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL366815 | 0.92 | MEN1 (0.45) | KDM4EALDH1A1MEN1KMT2AL3MBTL1 | |
| SCHEMBL367690 | 0.91 | MEN1 (0.43) | KDM4EALDH1A1MEN1KMT2AL3MBTL1 | |
| SCHEMBL366530 | 0.89 | CYP11B1 (0.35) | ALDH1A1MEN1KMT2AL3MBTL1MAPK1 | |
| SCHEMBL365113 | 0.88 | ALDH1A1 (0.41) | KDM4EALDH1A1MEN1KMT2AL3MBTL1 | |
| SCHEMBL365188 | 0.86 | CYP11B1 (0.39) | ALDH1A1KMT2ALMNACYP11B1CYP11B2 | |
| SCHEMBL366611 | 0.84 | ACHE (0.38) | KDM4EALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL366617 | 0.84 | MEN1 (0.45) | KDM4EALDH1A1MEN1KMT2AL3MBTL1 | |
| SCHEMBL365985 | 0.83 | MEN1 (0.46) | KDM4EALDH1A1MEN1KMT2AL3MBTL1 | |
| SCHEMBL365102 | 0.82 | KDM4E (0.41) | KDM4EALDH1A1MEN1KMT2AL3MBTL1 | |
| SCHEMBL366850 | 0.80 | MAPT (0.37) | KDM4EALDH1A1MEN1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | claimed |
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | disclosed |